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Cutaneous Leishmaniasis

  • Mansour Nassiri Kashani
  • Ali Khamesipour
  • Alireza Firooz
Chapter

Abstract

Leishmaniasis is a vector-borne disease, caused by more than 20 different species of the protozoan parasite Leishmania, transmitted to humans by 30 species of various sand flies. Leishmania infection depends upon the causative species and the host genetic profile which governs the immune responses. The disease may be clinically presented as cutaneous (CL), mucocutaneous (MCL), and visceral leishmaniasis (VL) with post-kala-azar dermal leishmaniasis (PKDL) as a particular entity of the latter (Fig. 9.1).

References

  1. 1.
    Alvar J, Vélez ID, Bern C, et al. Leishmaniasis worldwide and global estimates of its incidence. PLoS One. 2012;7:e35671.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
  3. 3.
    Du R, Hotez PJ, Al-Salem WS, et al. Old world cutaneous leishmaniasis and refugee crises in the Middle East and North Africa. PLoS Negl Trop Dis. 2016;10:e0004545.  https://doi.org/10.1371/journal.pntd.0004545. eCollectionCrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Postigo JA. Leishmaniasis in the World Health Organization eastern Mediterranean region. Int J Antimicrob Agents. 2010;36:S62–5.CrossRefPubMedGoogle Scholar
  5. 5.
    Reithinger R, Dujardin JC, Louzir H, et al. Cutaneous leishmaniasis. Lancet Infect Dis. 2007;7:581.CrossRefPubMedGoogle Scholar
  6. 6.
    Gontijo B, de Carvalho ML. American cutaneous leishmaniasis. Rev Soc Bras Med Trop. 2003;36:71–80.CrossRefPubMedGoogle Scholar
  7. 7.
    Momeni AZ, Aminjavaheri M. Clinical picture of cutaneous leishmaniasis in Isfahan, Iran. Int J Dermatol. 1994;33:260–5.CrossRefPubMedGoogle Scholar
  8. 8.
    Dowlati Y. Cutaneous leishmaniasis: clinical aspects. Clin Dermatol. 1996;14:425–31.CrossRefPubMedGoogle Scholar
  9. 9.
    Sharifi I, Fekri AR, Aflatoonian MR, et al. Leishmaniasis recidivans among school children in Bam, South-East Iran, 1994–2006. Int J Dermatol. 2010;49:557–61.CrossRefPubMedGoogle Scholar
  10. 10.
    Markle WH, Makhoul K. Cutaneous leishmaniasis: recognition and treatment. Am Fam Physician. 2004;69:1455–6.PubMedGoogle Scholar
  11. 11.
    Goto H, Lindoso JAL. Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Rev Anti-Infect Ther. 2010;8:419–33.CrossRefPubMedGoogle Scholar
  12. 12.
    Khatami A, Firooz A, Gorouhi F, et al. Treatment of acute Old World cutaneous leishmaniasis: a systematic review of randomised controlled trials. J Am Acad Dermatol. 2007;57:335.e1–e29.CrossRefGoogle Scholar
  13. 13.
    González U, Pinart M, Reveiz L, et al. Interventions for Old World cutaneous leishmaniasis. Cochrane Database Syst 2008;Rev 8:CD005067.Google Scholar
  14. 14.
    Khatami A, Firooz A, Gorouhi F, et al. Systematic review of New World cutaneous leishmaniasis: several points. Int J Dermatol. 2009;48:201–2.CrossRefPubMedGoogle Scholar
  15. 15.
    Khatami A, Firooz A, Zartab H, et al. Cutaneous leishmaniasis. In: Maibach H, Gorouhi F, editors. Evidence based dermatology. 2nd ed. Shelton: PMPH-USA; 2011.Google Scholar
  16. 16.
    Cardona-Arias JA, Vélez ID, López-Carvajal L. Efficacy of thermotherapy to treat cutaneous leishmaniasis: a meta-analysis of controlled clinical trials. PLoSOne. 2015;10:e0122569.CrossRefGoogle Scholar
  17. 17.
    López-Carvajal L, Cardona-Arias JA, Zapata-Cardona MI. Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials. BMC Infect Dis. 2016;16:360.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    López-Carvajal L, Hoyos M, et al. Systematization of clinical studies on the efficacy of treatments for cutaneous leishmaniasis 1980-2015. Arch Med. 2016;12(3):8.  https://doi.org/10.3823/1307.CrossRefGoogle Scholar
  19. 19.
    Noazin S, Khamesipour A, Moulton LH, et al. Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis: a meta-analysis. Vaccine. 2009;27:4747–53.CrossRefPubMedGoogle Scholar
  20. 20.
    González U, Pinart M, Sinclair D, et al. Vector and reservoir control for preventing leishmaniasis. Cochrane Database Syst Rev. 2015;(8):CD008736.
  21. 21.
    Sofizadeh A, Vatandoorst H, Rassi Y, et al. Spatial analysis of the relation between rodent’s active burrows and incidence of zoonotic cutaneous leishmaniasis in Golestan province, northeastern of Iran. J Arthropod Borne Dis. 2016;10:569–76.PubMedPubMedCentralGoogle Scholar
  22. 22.
    Yaghoobi-Ershadi MR. Control of phlebotomine sand flies in Iran: a review article. J Arthropod Borne Dis. 2016;10:429–44.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mansour Nassiri Kashani
    • 1
  • Ali Khamesipour
    • 1
  • Alireza Firooz
    • 1
  1. 1.Center for Research and Training in Skin Diseases and LeprosyTehran University of Medical SciencesTehranIran

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