Ewing Sarcoma and Osteosarcoma

  • Matthew D. Hall
  • Nadia Laack
  • Daniel J. IndelicatoEmail author
Part of the Practical Guides in Radiation Oncology book series (PGRO)


  • Pediatric bone tumors are treated with multiagent systemic chemotherapy combined with surgery and/or radiation therapy for local therapy.


  1. 1.
    Yock TI, Krailo M, Fryer CJ, Donaldson SS, Miser JS, Chen Z, Bernstein M, Laurie F, Gebhardt MC, Grier HE, Tarbell NJ, Children’s Oncology Group (2006) Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children’s Oncology Group. J Clin Oncol 24(24):3838–3843CrossRefGoogle Scholar
  2. 2.
    Schuck A, Ahrens S, Paulussen M, Kuhlen M, Könemann S, Rübe C, Winkelmann W, Kotz R, Dunst J, Willich N, Jürgens H (2003) Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys 55(1):168–177CrossRefGoogle Scholar
  3. 3.
    Indelicato DJ, Keole SR, Shahlaee AH, Shi W, Morris CG, Gibbs CP Jr, Scarborough MT, Marcus RB Jr (2008) Long-term clinical and functional outcomes after treatment for localized Ewing’s tumor of the lower extremity. Int J Radiat Oncol Biol Phys 70(2):501–509. Epub 2007 Sep 12CrossRefGoogle Scholar
  4. 4.
    Krasin MJ, Xiong X, Wu S, Merchant TE (2005) The effects of external beam irradiation on the growth of flat bones in children: modeling a dose-volume effect. Int J Radiat Oncol Biol Phys 62(5):1458–1463CrossRefGoogle Scholar
  5. 5.
    Indelicato DJ, Keole SR, Shahlaee AH, Shi W, Morris CG, Gibbs CP Jr, Scarborough MT, Marcus RB Jr (2008) Impact of local management on long-term outcomes in Ewing tumors of the pelvis and sacral bones: the University of Florida experience. Int J Radiat Oncol Biol Phys 72(1):41–48. Epub 2008 Jan 30CrossRefPubMedGoogle Scholar
  6. 6.
    Donaldson SS (2004) Ewing sarcoma: radiation dose and target volume. Pediatr Blood Cancer 42(5):471–476CrossRefGoogle Scholar
  7. 7.
    Laskar S, Mallick I, Gupta T, Muckaden MA (2008) Post-operative radiotherapy for Ewing sarcoma: when, how and how much? Pediatr Blood Cancer 51(5):575–580. Scholar
  8. 8.
    Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, Ebb DH, Choy E, Raskin KA, Liebsch N, Hornicek FJ, Delaney TF (2011) Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer 117(19):4522–4530. Epub 2011 Mar 29CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Matthew D. Hall
    • 1
  • Nadia Laack
    • 2
  • Daniel J. Indelicato
    • 1
    • 3
    Email author
  1. 1.Department of Radiation OncologyUniversity of Florida College of MedicineGainesvilleUSA
  2. 2.Department of Radiation OncologyMayo ClinicRochesterUSA
  3. 3.University of Florida Health Proton Therapy InstituteJacksonvilleUSA

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