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Urothelial Cancer

  • Andreas Skolarikos
Chapter

Abstract

The epithelium covering the pyelocalyceal system of the kidney, the ureter, and the urinary bladder constitutes a common source of human cancer development. Together with prostate, breast, lung, and colorectal cancers, urothelial cancer constitutes the five most common human malignancies [1]. Among urothelial tumors, those originating from the urinary bladder are by far the most common, as they account for the 90–95% of all locations [2]. Upper urinary tract urothelial cell carcinomas (UTUCs) originating from the pyelocalyceal system and ureteric epithelium account for the rest 5–10% [1, 3–5]. It is estimated that approximately 10.1/105 men and 2.5/105 women are affected annually by bladder cancer. In comparison, the annual incidence of UTUC is 1–2/105 people, approximately [1–5]. Urothelial carcinoma is highly lethal as 4/105 of men and 1.1/105 of women with bladder cancer will annually die of the disease [6].

References

  1. 1.
    Munoz JJ, Ellison LM (2000) Upper tract urothelial neoplasms: incidence and survival during the last 2 decades. J Urol 164:1523–1525CrossRefGoogle Scholar
  2. 2.
    Ploeg M, Aben KK, Kiemeney LA (2009) The present and future burden of urinary bladder cancer in the world. World J Urol 27:289–293CrossRefGoogle Scholar
  3. 3.
    Hall MC, Womack S, Sagalowsky AI et al (1998) Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. Urology 52:594–601CrossRefGoogle Scholar
  4. 4.
    Margulis V, Shariat SF, Matin SF et al (2009) Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer 115:1224–1233CrossRefGoogle Scholar
  5. 5.
    Olgac S, Mazumdar M, Dalbagni G, Reuter VE (2004) Urothelial carcinoma of the renal pelvis: a clinicopathologic study of 130 cases. Am J Surg Pathol 28:1545–1552CrossRefGoogle Scholar
  6. 6.
    Ferlay J, Randi G, Bosetti C et al (2008) Declining mortality from bladder cancer in Europe. BJU Int 101:11–19PubMedGoogle Scholar
  7. 7.
    Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Bohle A, Palou-Redorta M, Roupret M (2011) EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. Eur Urol 59:997–1008CrossRefGoogle Scholar
  8. 8.
    Stenzl A, Cowan NC, De Santis M, Kuczyk MA, Merseburger AS, Ribal MJ, Sherif A, Witjes JA (2011) Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU Guidelines. Eur Urol 59:1009–1018CrossRefGoogle Scholar
  9. 9.
    Roupret M, Zigeuner R, Palou J, Boehle A, Kaasimen E, Sylvester R, Babjuk M, Oosterlinck W (2011) European Guidelines for the diagnosis and management of upper urinary tract urothelial cell carcinomas: 2011 update. Eur Urol 59:584–594CrossRefGoogle Scholar
  10. 10.
    Eble JN, Sauter G, Epstein JI et al (eds) (2004) Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, Lyon, FranceGoogle Scholar
  11. 11.
    Brierley JD et al (2017) TNM classification of malignant tumours. In: UICC International Union against cancer, 8th edn. Wiley-Blackwell, OxfordGoogle Scholar
  12. 12.
    Datta S, Allen G, Evans R et al (2002) Urinary tract ultrasonography in the evaluation of haematuria – a report of over 1,000 cases. Ann R Coll Surg Engl 84(3):203–205PubMedPubMedCentralGoogle Scholar
  13. 13.
    Dibb M, Noble D, Peh Y et al (2001) Ultrasonographic analysis of bladder tumors. J Clin Imaging 25:416–420CrossRefGoogle Scholar
  14. 14.
    Kim JK, Ahn HJ, Park T et al (2002) Virtual cystoscopy of the contrast filled bladder in patients with gross haematuria. Am J Roentgenol 179:763–768CrossRefGoogle Scholar
  15. 15.
    Dillman JR, Caoili EM, Cohan RH et al (2008) Detection of upper tract urothelial neoplasms: sensitivity of axial, coronal reformatted, and curved-planar reformatted image-types utilizing 16-row multi-detector CT urography. Abdom Imaging 33:707–716CrossRefGoogle Scholar
  16. 16.
    Wang LJ, Wong YC, Chuang CK, Huang CC, Pang ST (2009) Diagnostic accuracy of transitional cell carcinoma on multidetector computerized tomography urography in patients with gross haematuria. J Urol 181:524–531CrossRefGoogle Scholar
  17. 17.
    Wang LJ, Wong YC, Huang CC et al (2010) Multidetector computerized tomography urography is more accurate than excretory urography for diagnosing transitional cell carcinoma of the upper urinary tract in adults with haematuria. J Urol 183:48–55CrossRefGoogle Scholar
  18. 18.
    Tekes A, Kamel I, Imam K et al (2003) MR imaging features of transitional cell carcinoma of the urinary bladder. Am J Roentgenol 180(3):771–777CrossRefGoogle Scholar
  19. 19.
    Takahashi N et al (2010) Gadolinium enhanced magnetic resonance urography for upper tract malignancy. J Urol 180:1330CrossRefGoogle Scholar
  20. 20.
    Phillips B (1998) Oxford centre for evidence-based medicine levels of evidence. Updated by Jeremy Howick, Mar 2009Google Scholar
  21. 21.
    European Association of Urology guidelines (2017) Non-muscle invasive Bladder cancer. Section 5.9 available at uroweb.com
  22. 22.
    Kundra V, Silverman PM (2003) Imaging in oncology from the University of Texas M. D. Anderson Cancer Center. Imaging in the diagnosis, staging, and follow-up of cancer of the urinary bladder. AJR Am J Roentgenol 180(4):1045–1054CrossRefGoogle Scholar
  23. 23.
    Rajesh A et al (2011) Bladder cancer: evaluation of staging accuracy using dynamic MRI. Clin Radiol 66:1140CrossRefGoogle Scholar
  24. 24.
    Sobin L, Wittekind C (eds) (1997) TNM classification of malignant tumours. Wiley-Liss, Baltimore, MDGoogle Scholar
  25. 25.
    Dorfman RE et al (1991) Upper abdominal lymph nodes: criteria for normal size determined with CT. Radiology 180:319CrossRefGoogle Scholar
  26. 26.
    Harisnghani M, Barentsz J, Hahn P et al (2003) Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 348:2491–2499CrossRefGoogle Scholar
  27. 27.
    Swinnen G, Maes A, Pottel H et al (2010) FDG-PET/CT for the preoperative lymph node staging of invasive bladder cancer. Eur Urol 57(4):641–647CrossRefGoogle Scholar
  28. 28.
    Schmidt GP, Schoenberg SO, Reiser MF et al (2005) Whole-body MR imaging of bone marrow. Eur J Radiol 55(1):33–40CrossRefGoogle Scholar
  29. 29.
    Stenzl A, Witjes JA, Compérat E, Cowan NC, De Santis M, Kuczyk M, Lebret T, Ribal MJ, Sherif A. Guidelines on bladder cancer muscle-invasive and metastatic. http://www.uroweb.org/gls/pdf/07_Bladder%20Cancer_LR%20II.pdf

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Andreas Skolarikos
    • 1
  1. 1.Second Department of UrologySismanoglio Hospital, National and Kapodistrian University of AthensAthensGreece

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