PET/CT Staging of Rectal Carcinoma

  • Maria G. SkilakakiEmail author


This article focuses on the impact of 18F-FDG PET/CT on the management of rectal cancer. The current use of PET/CT in the diagnosis, initial staging, and detection of recurrence of the disease is discussed in the light of recent available data. Furthermore, this article presents the evolving role of PET/CT in radiation therapy planning and in the assessment of response to neoadjuvant chemotherapy and to locoregional treatment of liver metastases.


18F-FDG PET/CT Rectal cancer Staging Recurrence Therapy monitoring Radiotherapy planning 


  1. 1.
    De Geus-Oei LF, Vriens D, van Laarhoven HWM et al (2009) Monitoring and predicting response to therapy with 18F-FDG PET in colorectal cancer: a systematic review. J Nucl Med 50:43S–54SCrossRefGoogle Scholar
  2. 2.
    Raman SP, Chen Y, Fishman EK (2015) Evolution of imaging in rectal cancer: multimodality imaging with MDCT, MRI and PET. J Gastrointest Oncol 6(2):172–184PubMedPubMedCentralGoogle Scholar
  3. 3.
    N.C.C Network (2015) NCCN clinical practice guidelines in oncology: rectal cancer, version 1. 2016. J Natl Compr Cancer NetwGoogle Scholar
  4. 4.
    Agarwal A, Marcus C, Xiao J et al (2014) FDG PET/CT in the management of colorectal and anal cancers. AJR 203:1109–1119CrossRefGoogle Scholar
  5. 5.
    Ozis SE, Soydal C, Akyol C et al (2014) The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer. World J Surg Oncol 12:26–32CrossRefGoogle Scholar
  6. 6.
    Lonneux M (2008) FDG-PET and PET/CT in colorectal cancer. PET Clin 3:147–153CrossRefGoogle Scholar
  7. 7.
    O’Connor OJ, McDermott S, Slattery J et al (2011) The use of PET-CT in the assessment of patients with colorectal carcinoma. Int J Surg Oncol 2011:14 Article ID 846512Google Scholar
  8. 8.
    Patel DA, Chang ST, Goodman KA et al (2007) Impact of integrated PET/CT on variability of target volume delineation in rectal cancer. Technol Cancer Res Treat 6(1):31–36CrossRefGoogle Scholar
  9. 9.
    Cerny M, Dunet V, Prior JO et al (2016) Initial staging of locally advanced rectal cancer and regional lymph nodes. Comparison of diffusion-weighted MRI with 18F-FDG-PET/CT. Clin Nucl Med 41:289–295CrossRefGoogle Scholar
  10. 10.
    Jeong JH, Cho IH, ChuN KA et al (2016) Correlation between apparent diffusion coefficients and standardized uptake values in hybrid 18F-FDG PET/MR: preliminary results in rectal cancer. Nucl Med Mol Imaging 50:150–156CrossRefGoogle Scholar
  11. 11.
    Hebertson RA, Lee ST, Tebbutt N et al (2007) The expanding role of PET technology in the management of patients with colorectal cancer. Ann Oncol 18:1774–1781CrossRefGoogle Scholar
  12. 12.
    De Geus-Oei LF, Ruers TJM, Punt CJA et al (2006) FDG-PET in colorectal cancer. Cancer Imaging 6:S71–S81CrossRefGoogle Scholar
  13. 13.
    Delbeke D, Martin WH (2011) FDG PET and PET/CT for colorectal cancer. Methods Mol Biol 727:77–103CrossRefGoogle Scholar
  14. 14.
    Mosley CK, Schuster DM (2007) Practical PET/CT of the abdomen. In: Wani RL (ed) RSNA categorical course in diagnostic radiology—clinical PET and PET/CT imaging. RSNA, Chicago, pp 71–81Google Scholar
  15. 15.
    Maffione AM, Marzola MC, Caprici C, Calletti PM, Rubello D (2015) Value of 18F-FDG PET for predicting response to neoadjuvant therapy in rectal cancer: systematic review and meta-analysis. AJR 204:1261–1268CrossRefGoogle Scholar
  16. 16.
    Joye I, Deroose CM, Vandecaveye V, Haustermans K (2014) The role of diffusion-weighted MRI and 18F-FDG PET/CT in the prediction of pathologic complete response after radiochemotherapy for rectal cancer: a systematic review. Radiother Oncol 113:158–165CrossRefGoogle Scholar
  17. 17.
    Rymer B, Curtis NJ, Siddiqui MR, Chand M (2016) FDG PET/CT can assess the response of locally advanced rectal cancer to neoadjuvant chemoradiotherapy: evidence from meta-analysis and systematic review. Clin Nucl Med 41(5):371–375CrossRefGoogle Scholar
  18. 18.
    Koo PJ, Kim SJ, Chang S, Kwak JJ (2016) Interim fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomograopy to predict pathologic response to preoperative chemoradiotherapy and prognosis in patients with locally advanced rectal cancer. Clin Colorectal Cancer 15(4):e213–e219CrossRefGoogle Scholar
  19. 19.
    Guerra L, Niespolo R, Di Pisa G et al (2011) Change in glucose metabolism measured by 18F-FDG PET/CT as a predictor of histopathologic response to neoadjuvant treatment in rectal cancer. Abdom Imaging 36:38–45CrossRefGoogle Scholar
  20. 20.
    Gascini GL, Avallone A, Delrio P et al (2006) 18F FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. J Nucl Med 47:1241–1248Google Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Evangelismos General HospitalAthensGreece

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