PET/CT with [18F]FDG in Endometrial Cancer
Like most neoplasms, endometrial carcinoma does demonstrate an increased rate of glycolysis and takes up [18F]FDG. Imaging with [18F]FDG-PET/CT may play a role as a prognostic factor in endometrium cancer. Several studies have shown that there is a statistically significant correlation between SUVmax and FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, lymphovascular space involvement and tumour size. Also, they have demonstrated that high SUVmax was an independent prognostic factor for both disease-free survival (DFS) and overall survival (OS), p < 0.05 [1–3]. The analysis of survival ROC curve revealed SUVmax cutoff value of 17.7 to predict high risk of recurrence. Endometrial cancer patients with SUVmax higher than 17.7 were characterized by worse prognosis and lower overall survival .
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