Advertisement

Radiobiology of Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations

  • Rachel Pruitt
  • Michael Schulder
Chapter

Abstract

Stereotactic radiosurgery (SRS) has been defined as the use of concentrated ionizing radiation delivered to a stereotactically defined point in space [1, 2]. SRS was used to treat patients with arteriovenous malformations (AVMs) as early as the 1970s [1]. As many as 500,000 people in North America have AVMs [3]. With SRS, angiographic cures fall between 60 and 90% [3–5]. A consideration of the radiobiology of SRS will explain why tumors and vascular lesions respond to radiation differently, and why patients with AVMs are ideal candidates for radiosurgery.

References

  1. 1.
    Friedman WA, Bova FJ. Radiosurgery for arteriovenous malformations. Neurol Res. 2011;33(8):803–19.CrossRefPubMedGoogle Scholar
  2. 2.
    Santacroce A, Kamp MA, Budach W, Hänggi D. Radiobiology of radiosurgery for the central nervous system. Biomed Res Int. 2013;2013:362761.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Quinones-Hinojosa A. Schmidek & Sweet operative neurosurgical techniques: indications, methods, and results. London: Elsevier Health Sciences; 2012.Google Scholar
  4. 4.
    Schneider BF, Eberhard DA, Steiner LE. Histopathology of arteriovenous malformations after gamma knife radiosurgery. J Neurosurg. 1997;87(3):352–7.CrossRefPubMedGoogle Scholar
  5. 5.
    Touboul E, Al Halabi A, Buffat L, Merienne L, Huart J, Schlienger M, Lefkopoulos D, Mammar H, Missir O, Meder JF, Laurent A, Housset M. Single-fraction stereotactic radiotherapy: a dose-response analysis of arteriovenous malformation obliteration. Int J Radiat Oncol Biol Phys. 1998;41(4):855–61.CrossRefPubMedGoogle Scholar
  6. 6.
    Friedman WA. Stereotactic radiosurgery of intracranial arteriovenous malformations. Neurosurg Clin N Am. 2013;24(4):561–74.CrossRefPubMedGoogle Scholar
  7. 7.
    Hall EJ, Brenner DJ. The radiobiology of radiosurgery: rationale for different treatment regimes for AVMs and malignancies. Int J Radiat Oncol Biol Phys. 1993;25(2):381–5.CrossRefPubMedGoogle Scholar
  8. 8.
    Pollock BE, Meyer FB. Radiosurgery for arteriovenous malformations. J Neurosurg. 2004;101(3):390–2. Discussion 392.CrossRefPubMedGoogle Scholar
  9. 9.
    Song CW, Park H, Griffin RJ, Levitt SH. Technical basis of radiation therapy. Berlin: Springer; 2011.Google Scholar
  10. 10.
    Park H, Lyons JC, Griffin RJ, Lim BU, Song CW. Apoptosis and cell cycle progression in an acidic environment after irradiation. Radiat Res. 2000;153(3):295–304.CrossRefPubMedGoogle Scholar
  11. 11.
    Karlsson B, Lindquist C, Steiner L. Prediction of obliteration after gamma knife surgery for cerebral arteriovenous malformations. Neurosurgery. 1997;40(3):425–30. Discussion 430–1.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryHofstra Northwell School of MedicineHempsteadUSA

Personalised recommendations