Vitiligo pp 381-398 | Cite as

Surgical Therapies

  • Boon Kee Goh


Cellular grafting for vitiligo has evolved since its inception. Non-cultured cellular grafting has superseded cultured techniques as the preferred modus operandi in clinical practice. The reasons are straightforward: it can be completed in a few hours, does not require the use of xenobiotics (except trypsin) or culture media and is of significantly lower costs. Although it does not offer the possibility of cell expansion and cryopreservation for future transplant, this can be supplanted by harvesting a new piece ultrathin split skin graft. Under proper training, harvesting an ultrathin split skin graft (not beyond the papillary dermis) is fast and results in no or minimal scarring. Innovative methods to simplify non-cultured cellular grafting have also been successfully achieved.

Melanocytes can now be extracted not only from the epidermis for transplantation but from outer root sheath of hair follicles.

Non-cultured cellular grafting has proven to be a safe and effective surgical treatment for stable vitiligo, substantiated by various long-term studies over the last two decades. The imposition of strict legislative regulation on this technique is unwarranted and will only drive up cost and deprive patients’ access to this innovative procedure.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Boon Kee Goh
    • 1
  1. 1.Skin Physicians Pte LtdMount Elizabeth Medical CentreSingaporeSingapore

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