We have summarized in Table 33.1 the current status of our understanding of vitiligo pathomechanisms. We have tried to divide it into major fields and levels of evidence. Clearly, in vivo evidence in human disease comes first. In vitro work, which relies on cultures, can be viewed more cautiously because of artifacts caused by culture conditions, even though appropriate controls are used. Some animal models are probably relevant, but definitive evidence is lacking.
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