Systemic Treatment of Breast Cancer and Breast Reconstruction

  • Sergio D. Simon


Systemic treatment with chemotherapy and endocrine therapy is an integral part of the multidisciplinary treatment of breast cancer. Adjuvant treatment with the selective estrogen receptor modulator tamoxifen significantly improves disease-free and overall survival of breast cancer patients; however, it can interfere with coagulation and has been associated with complications when used during microsurgical breast reconstruction. Neoadjuvant and adjuvant chemotherapy, on the other hand, can potentially complicate breast reconstruction by impairing wound healing and by increasing infectious events. Nonetheless, there is no evidence in the medical literature that chemotherapy significantly interferes with surgical outcomes of plastic surgery. On the other hand, there has been a suggestion that breast reconstruction can cause a slight delay in the commencement of adjuvant of chemotherapy; this finding was not supported by other authors. In summary, the association of chemotherapy and breast reconstruction seems to be safe and feasible.


Breast cancer Breast reconstruction Systemic treatment Adjuvant chemotherapy Tamoxifen Infection Microsurgery 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Sergio D. Simon
    • 1
  1. 1.Hospital Israelita Albert EinsteinSão PauloBrazil

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