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Adjuvant Systemic Therapy in Breast Cancer

  • Shari GoldFarbEmail author
  • Wanqing Iris Zhi
Chapter

Abstract

Patients with early-stage breast cancer are treated with curative intent. The goal of adjuvant therapy is to improve overall survival [1, 2]. After surgery, although there is no evidence of gross remaining disease, patients still have a risk of relapse from occult micrometastatic disease. The goal of adjuvant systemic therapy is to decrease risk of recurrence while minimizing toxicities and overtreatment. Therefore, it is important to identify patient populations that will benefit most from treatment in order to avoid unnecessary toxicities [3–5]. Patients require different adjuvant therapies based on their risk of recurrence, stage of disease, and tumor biology. In this chapter, we will discuss systemic adjuvant therapy including endocrine therapy, chemotherapy, and HER2-targeted therapy [6, 7].

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medicine, Epidemiology and BioestatisticsMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Department of MedicineWeill Cornell Medical CenterNew YorkUSA
  3. 3.Departments of Medicine and Regional NetworkMemorial Sloan Kettering Cancer CenterNew YorkUSA

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