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Larynx and Hypopharynx Cancer

  • Christopher H. Chapman
  • Adam Garsa
Chapter

Abstract

This chapter will discuss the epidemiology, workup, and management of larynx and hypopharynx cancer, with an emphasis on radiation therapy technique and randomized trial evidence.

Keywords

Larynx Vocal cords Glottis Hypopharynx Squamous cell carcinoma Radiation therapy Chemoradiotherapy Larynx-preserving therapy Induction chemotherapy 

Notes

Acknowledgment

We thank Sunanda Pejavar MD, Eric K. Hansen MDb, Sue S. Yom MD, and Naomi R. Schechter MDa, for their work on the prior edition of this chapter.

References

  1. Aaltonen L-M, Rautiainen N, Sellman J, et al. Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy. Int J Radiat Oncol Biol Phys. 2014;90(2):255–60.CrossRefPubMedGoogle Scholar
  2. Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349:2091–8.CrossRefPubMedGoogle Scholar
  3. Forastiere AA, Zhang Q, Weber RS, et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013;31(7):845–52.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Lefebvre JL, Chevalier D, Luboinski B, et al. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of cancer phase III trial. EORTC head and neck cancer cooperative group. J Natl Cancer Inst. 1996;88:890–9.CrossRefPubMedGoogle Scholar
  5. Lefebvre JL, Andry G, Chevalier D, et al. Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891. Ann Oncol. 2012;23(10):2708–14.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Lefebvre JL, Pointreau Y, Rolland F, et al. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. J Clin Oncol. 2013;31(7):853–9.CrossRefPubMedGoogle Scholar
  7. Overgaard J, Hansen HS, Specht L, et al. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial. Lancet. 2003;362(9388):933–40.CrossRefPubMedGoogle Scholar
  8. Pointreau Y, Garaud P, Chapet S, et al. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst. 2009;101(7):498–506.CrossRefPubMedGoogle Scholar
  9. Rosenthal DI, Mohamed ASR, Weber RS, et al. Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: a 3-decade survey. Cancer. 2015;121(10):1608–19.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Trotti A, Zhang Q, Bentzen SM, et al. Randomized trial of hyperfractionation versus conventional fractionation in T2 squamous cell carcinoma of the vocal cord (RTOG 9512). Int J Radiat Oncol Biol Phys. 2014;89(5):958–63.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Wolf GT, Hong WK, Fisher SG, et al. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324(24):1685–90.Google Scholar
  12. Yamazaki H, Nishiyama K, Tanaka E, et al. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys. 2006;64(1):77–82.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Radiation OncologyUniversity of Southern CaliforniaLos AngelesUSA

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