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Tissue Bioengineering in Transplantation

  • Ravi Katari
  • Lauren Edgar
  • Kevin Enck
  • Andrea Peloso
  • Riccardo Tamburrini
  • Giuseppe Orlando
Chapter

Abstract

Organ transplantation has emerged in recent decades as one of the most effective modalities for the treatment of end-stage organ disease. Over 100,000 transplants are performed worldwide each year; however, the supply has not been able to keep up with increasing demand. Furthermore, transplant recipients are committed to a lifelong regimen of brutal immunosuppressive medications that themselves carry significant side effect profiles, influencing clinical outcomes. Recent advances in the fields of tissue engineering and regenerative medicine are beginning to offer alternative solutions that could potentially improve the longevity, functionality, and biocompatibility profiles of transplants. Decellularization technology to produce extracellular matrix scaffolds represents one of the most promising strategies currently under investigation. Such methods can produce bioengineered, transplantable organs using autologous cells that would bypass the need for immunosuppression and its associated side effects. Furthermore, bioengineering strategies in general are not bound by supply constraints imposed by organ donation.

Keywords

Transplantation Bioengineering and regeneration Scaffold ECM Decellularization Stem cells 

Abbreviations

ECM

Extracellular matrix

ESC

Embryonic stem cell

iPSC

Induced pluripotent stem cell

MSC

Mesenchymal stem cell

PEG

Polyethylene glycol

TE

Tissue engineering

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Ravi Katari
    • 1
  • Lauren Edgar
    • 1
  • Kevin Enck
    • 1
  • Andrea Peloso
    • 2
  • Riccardo Tamburrini
    • 1
  • Giuseppe Orlando
    • 3
    • 4
  1. 1.Wake Forest School of MedicineWinston SalemUSA
  2. 2.General Surgery, Fondazione IRCCS Policlinico San Matteo and University of PaviaPaviaItaly
  3. 3.Department of Surgery, Section of TransplantationWake Forest School of MedicineWinston SalemUSA
  4. 4.Wake Forest Baptist HospitalWinston SalemUSA

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