Small-Bowel Endoscopy

  • Paolo GandulliaEmail author
  • Tommaso Bellini


Small-bowel endoscopy is a recent technique that has been recently introduced in pediatric gastroenterology practice. It allows to explore a region previously unreachable by standard digestive endoscopy. Small-bowel endoscopy consists of two different techniques: the wireless capsule endoscopy and the balloon-assisted enteroscopy; there is no evidence that one technique is better than another and their use, combined or alone, has permitted diagnostic and therapeutic advances in small-bowel disease such as inflammatory bowel diseases, obscure gastrointestinal bleeding, vascular malformations, and polyps. In Crohn’s disease, small-bowel endoscopy is fundamental to evaluate the extension and to stage of the disease, and to perform a therapeutic intervention avoiding surgery.


Children Pediatrics Small-bowel endoscopy Wireless capsule endoscopy Balloon-assisted enteroscopy Single balloon enteroscopy Double balloon endoscopy Inflammatory bowel disease Crohn’s disease Obscure bleeding 


  1. 1.
    Steiner SJ. Deeper and deeper into the pediatric small bowel. Gastrointest Endosc. 2012;75(1):95–7. Scholar
  2. 2.
    Barth BA, Channabasappa N. Single-balloon enteroscopy in children: initial experience at a pediatric center. J Pediatr Gastroenterol Nutr. 2010;51(5):680–4. Scholar
  3. 3.
    deRidder L, Tabbers MM, Escher JC. Small bowel endoscopy in children. Best Pract Res Clin Gastroenterol. 2012;26(3):337–45. Scholar
  4. 4.
    Chen WG, Shan GD, Zhang H, Yang M, L L, Yue M, et al. Double-balloon enteroscopy in small bowel diseases: eight years single-center experience in China. Medicine (Baltimore). 2016;95(42):e5104.CrossRefGoogle Scholar
  5. 5.
    ASGE Standards of Practice Committee, Khashab MA, Pasha SF, Muthusamy VR, Acosta RD, Bruining DH, Chandrasekhara V, et al. The role of deep enteroscopy in the management of small-bowel disorders. Gastrointest Endosc. 2015;82(4):600–7. Scholar
  6. 6.
    Yokoyama K, Yano T, Kumagai H, Mizuta K, Ono S, Imagawa T, et al. Double-balloon enteroscopy for pediatric patients: evaluation of safety and efficacy in 257 cases. J Pediatr Gastroenterol Nutr. 2016;63(1):34–40. CrossRefPubMedGoogle Scholar
  7. 7.
    Cohen SA, Ephrath H, Lewis JD, Klevens A, Bergwerk A, Liu S, et al. Pediatric capsule endoscopy: review of the small bowel and patency capsules. J Pediatr Gastroenterol Nutr. 2012;54(3):409–13. Scholar
  8. 8.
    Mishkin DS, Chuttani R, Croffie J, Disario J, Liu J, Shah R, et al. ASGE Technology Status Evaluation Report: wireless capsule endoscopy. Gastrointest Endosc. 2006;63(4):539–45.CrossRefGoogle Scholar
  9. 9.
    Koulaouzidis A, Iakovidis DK, Yung DE, Rondonotti E, Kopylov U, Plevris JN, et al. KID Project: an internet-based digital video atlas of capsule endoscopy for research purposes. Endosc Int Open. 2017;5(6):E477–83. Scholar
  10. 10.
    Di Nardo G, Oliva S, Aloi M, Rossi P, Casciani E, Masselli G, et al. Usefulness of single-balloon enteroscopy in pediatric Crohn’s disease. Gastrointest Endosc. 2012;75(1):80–6. Scholar
  11. 11.
    Friedlander JA, Liu QY, Sahn B, Kooros K, Walsh CM, Kramer RE, et al. NASPGHAN Capsule Endoscopy Clinical Report. J Pediatr Gastroenterol Nutr. 2017;64(3):485–94. CrossRefPubMedGoogle Scholar
  12. 12.
    de’Angelis GL, Fornaroli F, de’Angelis N, Magiteri B, Bizzarri B. Wireless capsule endoscopy for pediatric small-bowel diseases. Am J Gastroenterol. 2007;102(8):1749–57.CrossRefGoogle Scholar
  13. 13.
    Di Nardo G, de Ridder L, Oliva S, Casciani E, Escher JC, Cucchiara S. Enteroscopy in paediatric Crohn’s disease. Dig Liver Dis. 2013;45(5):351–5. Scholar
  14. 14.
    Danialifar TF, Naon H, Liu QY. Comparison of diagnostic accuracy and concordance of video capsule endoscopy and double balloon enteroscopy in children. J Pediatr Gastroenterol Nutr. 2016;62(6):824–7. Scholar
  15. 15.
    deRidder L, Mensink PB, Lequin MH, Aktas H, de Krijger RR, van der Woude CJ, et al. Single-balloon enteroscopy, magnetic resonance enterography, and abdominal US useful for evaluation of small-bowel disease in children with (suspected) Crohn’s disease. Gastrointest Endosc. 2012;75(1):87–94. Scholar
  16. 16.
    Tringali A, Thomson M, Dumonceau JM, Tavares M, Tabbers MM, Furlano R, et al. Pediatric gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guideline executive summary. Endoscopy. 2017;49(1):83–91. Scholar
  17. 17.
    Rahman A, Ross A, Leighton JA, Schembre D, Gerson L, Lo SK, et al. Double-balloon enteroscopy in Crohn’s disease: findings and impact on management in a multicenter retrospective study. Gastrointest Endosc. 2015;82(1):102–7. Scholar
  18. 18.
    Di Nardo G, Oliva S, Ferrari F, Riccioni ME, Staiano A, Lombardi G, et al. Usefulness of wireless capsule endoscopy in paediatric inflammatory bowel disease. Dig Liver Dis. 2011;43(3):220–4. Scholar
  19. 19.
    Levine A, Koletzko S, Turner D, Escher JC, Cucchiara S, de Ridder L, et al. ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr. 2014;58(6):795–806. CrossRefPubMedGoogle Scholar
  20. 20.
    Uchida K, Yoshiyama S, Inoue M, Koike Y, Yasuda H, Fujikawa H, et al. Double balloon enteroscopy for pediatric inflammatory bowel disease. Pediatr Int. 2012;54(6):806–9. Scholar
  21. 21.
    Shen R, Sun B, Gong B, Zhang S, Cheng S. Double-balloon enteroscopy in the evaluation of small bowel disorders in pediatric patients. Dig Endosc. 2012;24(2):87–92.; Epub 2011 Jul 13.CrossRefPubMedGoogle Scholar
  22. 22.
    Jensen MK, Tipnis NA, Bajorunaite R, Sheth MK, Sato TT, Noel RJ. Capsule endoscopy performed across the pediatric age range: indications, incomplete studies, and utility in management of inflammatory bowel disease. Gastrointest Endosc. 2010;72(1):95–102. Scholar
  23. 23.
    Herle K, Jehangir S. Retained wireless capsule endoscope in a girl with suspected Crohn’s disease. APSP J Case Rep. 2016;7(4):27. Scholar
  24. 24.
    Moreels TG, Di Nardo G. The next novelty in pediatric endoscopy: enteroscopy. J Pediatr Gastroenterol Nutr. 2014;58(2):141–2. Scholar
  25. 25.
    Oliva S, Pennazio M, Cohen SA, Aloi M, Barabino A, Hassan C, et al. Capsule endoscopy followed by single balloon enteroscopy in children with obscure gastrointestinal bleeding: a combined approach. Dig Liver Dis. 2015;47(2):125–30. Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Gastroenterology UnitG. Gaslini Institute for Maternal and Child Health, IRCCSGenoaItaly

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