Gastroesophageal Reflux Disease and Helicobacter pylori in Children
There is a complex relationship among H. pylori, gastric acid production, and the development of reflux symptoms and disease. Studies that fail to address this complexity will not provide clear information on which to base clinical decisions and still not well understood in adults as well as in children.
The implications of H. pylori infection for the acquisition of GERD are a matter of current controversy. Some studies suggest a causative association between H. pylori infection and GERD, whereas others postulate a protective role for H. pylori infection. On balance and based on the pediatric published data, we consider that H. pylori eradication more likely to provide benefits than harm in children with GERD.
Frequency of GERD and clinical manifestations of H. pylori infection; relationship of H. pylori and erosive reflux disease; relationship of GERD and H. pylori CagA and VacA and other genes’ status; effect of H. pylori and type of gastritis on gastrin, ghrelin, motilin, and GERD; influence of H. pylori eradication on GERD symptoms; and, finally, influence of H. pylori on the development of EoE in children were all summarized in this chapter.
KeywordsGER H. pylori Child Esophagitis
Cytotoxin-associated gene A
Ear nose throat
Eosinophils per high-power field
Gastroesophageal reflux disease
- H. pylori
Lower esophageal sphincter pressure
Nonerosive reflux disease
Rapid urease test
Recurrent abdominal pain
Polymerase chain reaction
Proton pump inhibitor
- upper GI endoscopy
Upper gastrointestinal endoscopy
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