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Duodenogastroesophageal Reflux

  • Ilse Hoffman
Chapter

Abstract

Gastroesophageal reflux disease is a multifactorial disorder in children and adults and results from reflux of gastric contents into the esophagus. Animal studies suggest the possibility of synergism between acid and pepsin and conjugated bile acids with a damaging potential for the esophageal mucosa. Human studies show an interaction between acid and duodenogastroesophageal reflux in inducing lesions. Gastroesophageal reflux symptoms are more related to acid reflux events than to non-acid reflux events. The role of duodenogastroesophageal reflux has been evaluated by endoscopy with biopsies, scintigraphy, aspiration studies, esophageal pH-monitoring/impedance, and bilirubin monitoring. Therapeutic options are reducing the secretion of gastric acid, prokinetics, baclofen, surgery, and mucosal protective agents.

Keywords

Bile reflux Non-acid reflux Alkaline reflux Duodenogastroesophageal reflux Gastroesophageal reflux Gastroesophageal reflux disease Reflux esophagitis Children Bilitec Reference value bilitec Bilirubin monitoring pH-monitoring/impedance Barrett’s mucosa Bile salt Bile acids 

Abbreviations

DGER

Duodenogastroesophageal reflux

GERD

Gastroesophageal reflux disease

GI

Gastrointestinal

PPI

Proton pump inhibitor

ROS

Reactive oxygen species

TEER

Transepithelial resistance

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.University Hospitals LeuvenLeuvenBelgium

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