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Cellular and Genetic Programs Underlying Cerebellum Development

  • Alexandra L. JoynerEmail author
  • Ryan Willett
  • Andrew Lawton
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

The cerebellum is a late developing structure compared to the rest of the central nervous system (CNS) and houses more cells than the entire rest of the brain in a complex set of folds. To accommodate production of the large number of cells, the cerebellum has not only a ventricular progenitor zone that produces all the glia and inhibitory neurons but also a unique progenitor zone, the rhombic lip, dedicated to excitatory neuron production. In this chapter we discuss how the inhibitory Purkinje cells, which integrate the incoming information and moderate the output neurons of the cerebellar nuclei, play a key role during development in ensuring appropriate production of the other neurons/astrocytes of the cerebellar cortex. Key transcription factors that regulate development of the two progenitor populations and the lineage relationships of the neurons and astrocytes produced by each are described, followed by a discussion of cerebellar foliation.

Keywords

Ventricular zone Rhombic lip Purkinje cells Granule cells Interneurons Bergmann glia Astrocytes Cerebellar nuclei Neural stem cells Foliation 

Notes

Acknowledgments

We thank members of the Joyner lab, past and present, for stimulating discussions about cerebellum development. Our cerebellar research is supported by grants to ALJ from the NIH (R37MH085726, R01NS092096, and R01CA192176) and by NIH Kirschstein National Research Service Awards to RW (F32NS080422) and AL (F32NS086163) and a National Cancer Institute Cancer Center Support Grant No 2 (P30 CA008748-48).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Alexandra L. Joyner
    • 1
    Email author
  • Ryan Willett
    • 1
  • Andrew Lawton
    • 1
  1. 1.Developmental Biology Program, Memorial Sloan Kettering Cancer Center, and Weill Cornell Graduate ProgramNew YorkUSA

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