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Infections of the Cerebellum

  • Kevin M. CoombsEmail author
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

Infectious diseases still account for a significant amount of morbidity and mortality, particularly in developing countries. Although the Lancet’s latest Global Burden of Disease report indicates life expectancy has increased dramatically during the past decade, partly because of similar dramatic declines in infectious disease-related deaths, estimates are that nearly ten million people die yearly from communicable diseases or from complications arising from prior infection (e.g., liver cirrhosis or liver cancer after hepatitis B and hepatitis C virus infection). Infectious agents include organisms from multiple taxonomic groups and are categorized as bacteria, fungi, viruses, and others. Bacteria and fungi belong to separate taxonomic kingdoms. Viruses are unique and are generally considered to fall outside normal life taxonomy; however, they are, as a group, responsible for more suffering than any other group of infectious agents. Infectious diseases affect every organ system in the body. This chapter will focus on those agents that affect the human central nervous system, with more focus on the cerebellum.

Keywords

Virus Replication Cerebellar ataxia 

Notes

Acknowledgments

Research in my laboratory has been supported by grants MT-11630 and MOP-106713 from the Canadian Institutes of Health Research.

References

  1. 1.
    Abul-Kasim K, Palm L, Maly P, Sundgren PC. The neuroanatomic localization of Epstein-Barr virus encephalitis may be a predictive factor for its clinical outcome: a case report and review of 100 cases in 28 reports. J Child Neurol. 2009;24:720–6.PubMedCrossRefPubMedCentralGoogle Scholar
  2. 2.
    Ali G, Rashid S, Kamli MA, Shah PA, Allaqaband GQ. Spectrum of neuropsychiatric complications in 791 cases of typhoid fever. Trop Med Int Health. 1997;2:314–8.PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Amet T, Ghabril M, Chalasani N, Byrd D, Hu NJ, Grantham A, Liu ZQ, Qin XB, He JJ, Yu QG. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 2012;55:354–63.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Arav-Boger R, Crawford T, Steere AC, Halsey NA. Cerebellar ataxia as the presenting manifestation of Lyme disease. Pediatr Infect Dis J. 2002;21:353–6.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    Aydin M, Ozcelik U, Cevik H, Cinar O, Evren E, Demirag A. Multiple brain abscesses due to Phialemonium in a renal transplant recipient: first case report in the literature. Exp Clin Transplant. 2015;13:77–80.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Baltimore D. Expression of animal virus genomes. Bacteriol Rev. 1971;35:235–41.PubMedPubMedCentralGoogle Scholar
  7. 7.
    Barkovich AJ. Infections of the nervous system. In: Barkovich AJ, editor. Pediatric neuroimaging. Philadelphia: Lippincott-Raven; 1996. p. 569–617.Google Scholar
  8. 8.
    Bell WR, Dalton JB, McCall CM, Karram S, Pearce DT, Memon W, Lee R, Carroll KC, Lyons JL, Gireesh ED, Trivedi JB, Cettomai D, Smith BR, Chang T, Tochen L, Ratchford JN, Harrison DM, Ostrow LW, Stevens RD, Chen L, Zhang SX. Iatrogenic Exserohilum infection of the central nervous system: mycological identification and histopathological findings. Mod Pathol. 2013;26:166–70.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    Berger RP, Wadowksy RM. Rhabdomyolysis associated with infection by Mycoplasma pneumoniae: a case report. Pediatrics. 2000;105:433–6.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Calabria F, Zappini F, Vattemi G, Tinazzi M. Pearls & Oy-sters: an unusual case of varicella-zoster virus cerebellitis and vasculopathy. Neurology. 2014;82:E14–5.PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Campos LG, Trindade RA, Faistauer A, Perez JA, Vedolin LM, Duarte JA. Rhombencephalitis: pictorial essay. Radiol Bras. 2016;49:329–36.PubMedCrossRefPubMedCentralGoogle Scholar
  12. 12.
    Chen LN, Shi Q, Zhang BY, Zhang XM, Wang J, Xiao K, Lv Y, Sun J, Yang XD, Chen C, Zhou W, Han J, Dong XP. Proteomic analyses for the global S-nitrosylated proteins in the brain tissues of different human prion diseases. Mol Neurobiol. 2016;53:5079–96.PubMedCrossRefPubMedCentralGoogle Scholar
  13. 13.
    Chen S, Pu JL, Yu J, Zhang JM. Multiple aspergillus cerebellar abscesses in a middle-aged female: case report and literature review. Int J Med Sci. 2011;8:635–9.PubMedCrossRefPubMedCentralGoogle Scholar
  14. 14.
    Chertow DS, Nath A, Suffredini AF, Danner RL, Reich DS, Bishop RJ, Childs RW, Arai AE, Palmore TN, Lane HC, Fauci AS, Davey RT. Severe meningoencephalitis in a case of Ebola virus disease: a case report. Ann Intern Med. 2016;165:301–4.PubMedCrossRefPubMedCentralGoogle Scholar
  15. 15.
    Cho TA, Schmahmann JD, Cunnane ME. Case 30-2013: a 19-year-old man with otalgia, slurred speech, and ataxia. New Engl J Med. 2013;369:1253–61.PubMedCrossRefPubMedCentralGoogle Scholar
  16. 16.
    Choudhury N, Khan AB, Tzvetanov I, Garcia-Roca R, Oberholzer J, Benedetti E, Jeon H. Cerebellar abscess caused by Listeria monocytogenes in a liver transplant patient. Transpl Infect Dis. 2013;15:E224–8.PubMedCrossRefPubMedCentralGoogle Scholar
  17. 17.
    Compain C, Sacre K, Puechal X, Klein I, Vital-Durand D, Houeto JL, De Broucker T, Raoult D, Papo T. Central nervous system involvement in whipple disease clinical study of 18 patients and long-term follow-up. Medicine. 2013;92:324–30.PubMedPubMedCentralGoogle Scholar
  18. 18.
    Curnen EC, Chamberlin HR. Acute cerebellar ataxia associated with poliovirus infection. Yale J Biol Med. 1961;34:219. &PubMedPubMedCentralGoogle Scholar
  19. 19.
    Cutroneo PM, Italiano D, Trifiro G, Tortorella G, Russo A, Isola S, Caputi AP, Spina E. Acute cerebellar ataxia following meningococcal group C conjugate vaccination. J Child Neurol. 2014;29:128–30.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Dang L, Dang X, Koralnik IJ, Todd PK. JC polyomavirus granule cell neuronopathy in a patient treated with rituximab. JAMA Neurol. 2014;71:487–9.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Davis LE, DeBiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters BK, Tyler KL. West Nile virus neuroinvasive disease. Ann Neurol. 2006;60:286–300.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    de Fatima Vasco Aragao M, van der Linden V, Brainer-Lima AM, Coeli RR, Rocha MA, Sobral da Silva P, Durce Costa Gomes de Carvalho M, van der Linden A, Cesario de Holanda A, Valenca MM. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ. 2016;353:i1901.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    De Santis P, Della Marca G, Di Lella G, Cavallaro F. Sub-acute hydrocephalus in a patient with influenza A (H3N2) virus-related cerebellitis. J Neurol Neurosur Ps. 2012;83:1091–2.CrossRefGoogle Scholar
  24. 24.
    Dean DJ, Mcclure RC, Evans WM. Pathogenesis of rabies. Bull WHO. 1963;29:803. &PubMedPubMedCentralGoogle Scholar
  25. 25.
    Ejaz A, Steinmann E, Banki Z, Anggakusuma, Khalid S, Lengauer S, Wilhelm C, Zoller H, Schloegl A, Steinmann J, Grabski E, Kleines M, Pietschmann T, Stoiber H. Specific acquisition of functional CD59 but not CD46 or CD55 by hepatitis C virus. PLoS One. 2012;7:e45770.PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Endo H, Kumabe T, Kon H, Yoshimoto T, Nakasato Y. A case of primary cerebellar glioblastoma in childhood. Neurol Surg Tokyo. 2002a;30:1325–9.Google Scholar
  27. 27.
    Endo T, Tominaga T, Konno H, Yoshimoto T. Fatal subarachnoid hemorrhage, with brainstem and cerebellar infarction, caused by Aspergillus infection after cerebral aneurysm surgery: case report. Neurosurgery. 2002b;50:1147–9.PubMedPubMedCentralGoogle Scholar
  28. 28.
    Erol I, Saygi S, Alehan F. Acute cerebellar ataxia in a pediatric case of Lyme disease and a review of literature. Pediatr Neurol. 2013;48:407–10.PubMedCrossRefPubMedCentralGoogle Scholar
  29. 29.
    Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet. 2011;377:849–62.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    Ferrer I, Bianco R, Marti E. Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzeldt-Jakob disease. Brain Pathol. 2000;10:665.Google Scholar
  31. 31.
    Gheuens S, Pierone G, Peeters P, Koralnik IJ. Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosur Ps. 2010;81:247–54.CrossRefGoogle Scholar
  32. 32.
    Grahn A, Studahl M. Varicella-zoster virus infections of the central nervous system – prognosis, diagnostics and treatment. J Inf Infect. 2015;71:281–93.CrossRefGoogle Scholar
  33. 33.
    Grant JK, Yin NC, Zaytoun AM, Waseem H, Hobbs JA. Persistent adeno-associated virus 2 and parvovirus B19 sequences in post-mortem human cerebellum. Cerebellum. 2009;8:490–8.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Greco F, Barbagallo ML, Chiodo DC, Guglielmino R, Sorge G. Severe ataxia as a complication of human parvovirus B19 acute encephalitis in a child. J Child Neurol. 2008;23:1078–80.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Guleria R, Nisar N, Chawla TC, Biswas NR. Mycoplasma pneumoniae and central nervous system complications: a review. J Lab Clin Med. 2005;146:55–63.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Hegde V, Aziz Z, Kumar S, Bhat M, Prasad C, Gupta AK, Netravathi M, Saini J. Dengue encephalitis with predominant cerebellar involvement: report of eight cases with MR and CT imaging features. Eur Radiol. 2015;25:719–25.PubMedCrossRefPubMedCentralGoogle Scholar
  37. 37.
    Imbeault M, Ouellet M, Giguere K, Bertin J, Belanger D, Martin G, Tremblay MJ. Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol. 2011;85:2189–200.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Incecik F, Herguner MO, Mert G, Alabaz D, Altunbasak S. Acute cerebellar ataxia associated with enteric fever in a child: a case report. Turk J Pediatr. 2013;55:441–2.PubMedPubMedCentralGoogle Scholar
  39. 39.
    Iranpour M, Moghadam AR, Yazdi M, Ande SR, Alizadeh J, Wiechec E, Lindsay R, Drebot M, Coombs KM, Ghavami S. Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis. Expert Rev Mol Med. 2016;18:e1.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Iwasaki Y, Yokoi F, Tatsumi S, Mimuro M, Iwai K, Kitamoto T, Yoshida M. An autopsied case of Creutzfeldt-Jakob disease with mutation in the prion protein gene codon 232 and type 1+2 prion protein. Neuropathology. 2013;33:568–75.PubMedPubMedCentralGoogle Scholar
  41. 41.
    Kalina P, Decker A, Kornel E, Halperin JJ. Lyme disease of the brainstem. Neuroradiology. 2005;47:903–7.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Kalita J, Kumar P, Misra UK. Stimulus-sensitive myoclonus and cerebellar ataxia following chikungunya meningoencephalitis. Infection. 2013;41:727–9.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Karunarathne S, Udayakumara Y, Fernando H. Epstein-Barr virus co-infection in a patient with dengue fever presenting with post-infectious cerebellitis: a case report. J Med Case Rep. 2012;6:43.PubMedCrossRefPubMedCentralGoogle Scholar
  44. 44.
    Katafuchi Y, Aida K, Shiotsuki Y, Yamashita Y, Horikawa M, Andou H. Acute cerebellar ataxia and facial palsy after DPT immunization. No To Hattatsu. 1989;21:465–9.PubMedPubMedCentralGoogle Scholar
  45. 45.
    Kato Z, Sasai H, Funato M, Asano T, Kondo N. Acute cerebellitis associated with rotavirus infection. World J Pediatr. 2013;9:87–9.PubMedCrossRefPubMedCentralGoogle Scholar
  46. 46.
    King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ. Virus taxonomy. Ninth report of the international committee on taxonomy of viruses. San Diego: Academic; 2012.Google Scholar
  47. 47.
    Kubota M, Takahashi Y. Steroid-responsive chronic cerebellitis with positive glutainate receptor delta 2 antibody. J Child Neurol. 2008;23:228–30.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Kubota T, Suzuki T, Kitase Y, Kidokoro H, Miyajima Y, Ogawa A, Natsume J, Okumura A. Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy. Brain Dev-Jpn. 2011;33:21–7.CrossRefGoogle Scholar
  49. 49.
    La Scola B, Desnues C, Pagnier I, Robert C, Barrassi L, Fournous G, Merchat M, Suzan-Monti M, Forterre P, Koonin E, Raoult D. The virophage as a unique parasite of the giant mimivirus. Nature. 2008;455:100–U65.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Lau KK, Lai ST, Lai JY, Yan WW, So TM, Wong TY. Acute encephalitis complicating rubella. Hong Kong Med J. 1998;4:325–8.PubMedPubMedCentralGoogle Scholar
  51. 51.
    Legendre M, Bartoli J, Shmakova L, Jeudy S, Labadie K, Adrait A, Lescot M, Poirot O, Bertaux L, Bruley C, Coute Y, Rivkina E, Abergel C, Claverie JM. Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. P Natl Acad Sci USA. 2014;111:4274–9.CrossRefGoogle Scholar
  52. 52.
    Lippe R. Deciphering novel host-herpesvirus interactions by virion proteomics. Front Microbiol. 2012;3:181.PubMedCrossRefPubMedCentralGoogle Scholar
  53. 53.
    Mahadevan A, Suja MS, Mani RS, Shankar SK. Perspectives in diagnosis and treatment of rabies viral encephalitis: insights from pathogenesis. Neurotherapeutics. 2016;13:477–92.PubMedCrossRefPubMedCentralGoogle Scholar
  54. 54.
    Matthews BR, Jones LK, Saad DA, Aksamit AJ, Josephs KA. Cerebellar ataxia and central nervous system Whipple disease. Arch Neurol. 2005;62:618–20.PubMedCrossRefPubMedCentralGoogle Scholar
  55. 55.
    McMinn PC. Enterovirus vaccines for an emerging cause of brain-stem encephalitis. New Engl J Med. 2014;370:792–4.PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Mendel E, Khoo LT, Go JL, Hinton D, Zee CS, Apuzzo MLJ. Intracerebral Whipple’s disease diagnosed by stereotactic biopsy: a case report and review of the literature. Neurosurgery. 1999;44:203–9.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, Kolenc M, Rus KR, Vipotnik TV, Vodusek VF, Vizjak A, Pizem J, Petrovec M, Zupanc TA. Zika virus associated with microcephaly. New Engl J Med. 2016;374:951–8.PubMedCrossRefPubMedCentralGoogle Scholar
  58. 58.
    Molina OM, Morales MC, Soto ID, Pena JA, Haack RS, Cardozo DP, Cardozo JJ. Venezuelan equine encephalitis. 1995 outbreak: clinical profile of the cases with neurologic involvement. Rev Neurol. 1999;29:296–8.PubMedPubMedCentralGoogle Scholar
  59. 59.
    Montenegro MA, Santos SLM, Li LM, Cendes F. Neuroimaging of acute cerebellitis. J Neuroimaging. 2002;12:72–4.PubMedCrossRefPubMedCentralGoogle Scholar
  60. 60.
    Moses H, Nagel MA, Gilden DH. Acute cerebellar ataxia in a 41 year old woman. Lancet Neurol. 2006;5:984–8.PubMedCrossRefPubMedCentralGoogle Scholar
  61. 61.
    Murthy JM, Kishore LT. MR findings in cerebellar ataxia after enteric fever. J Comput Assist Tomogr. 1997;21:216–7.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Mustafa M, Levin J, Schoberl F, Rominger A. Postinfectious opsoclonus-myoclonus syndrome in a 41-year-old patient visualizing hyperactivation in deep cerebellar nuclei by cerebral [F-18]-FDG- PET. J Neuroimaging. 2015;25:683–5.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Narita M. Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis. Front Microbiol. 2016;7:23.PubMedCrossRefPubMedCentralGoogle Scholar
  64. 64.
    Naselli A, Pala G, Cresta F, Finetti M, Biancheri R, Renna S. Acute post-infectious cerebellar ataxia due to co-infection of human herpesvirus-6 and adenovirus mimicking myositis. Ital J Pediatr. 2014;40:98.PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Pisa D, Alonso R, Rabano A, Rodal I, Carrasco L. Different brain regions are infected with fungi in Alzheimer’s disease. Sci Rep-Uk. 2015;5:15015.CrossRefGoogle Scholar
  66. 66.
    Prieto JM, Pardo J, Lopez J, Lema M, Castillo J, Noya M. Rhombencephalitis caused by Listeria monocytogenes. Neurologia. 1992;7:270–3.PubMedPubMedCentralGoogle Scholar
  67. 67.
    Pruitt AA. Infections of the cerebellum. Neurol Clin. 2014;32:1117–31.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    Ramalho Rocha, Y. R., Cavalcanti Costa, J. R., Almeida Costa, P., Maia, G., Vasconcelos Rde, M., Ramos Tejo, C., Martins Batista, R., Lima Neto, M., Martins de Lima, G. G., Negromonte, F., Borba, M., Bezerra Jeronimo, S. M., Sequerra, E. B., Moreira Neto, M.. Radiological characterization of cerebral phenotype in newborn microcephaly cases from 2015 outbreak in Brazil. PLoS Curr. 2016;8, e854dbf51b8075431a05b39042c00244.Google Scholar
  69. 69.
    Ratzka P, Schlachetzki JCM, Bahr M, Nau R. Varicella zoster virus cerebellitis in a 66-year-old patient without herpes zoster. Lancet. 2006;367:182.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Saifuddin M, Parker CJ, Peeples ME, Gorny MK, Zollapazner S, Ghassemi M, Rooney IA, Atkinson JP, Spear GT. Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1. J Exp Med. 1995;182:501–9.PubMedCrossRefPubMedCentralGoogle Scholar
  71. 71.
    Salimi H, Cain MD, Klein RS. Encephalitic arboviruses: emergence, clinical presentation, and neuropathogenesis. Neurotherapeutics. 2016;13:514–34.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Schmahmann JD. Plasmapheresis improves outcome in postinfectious cerebellitis induced by Epstein-Barr virus. Neurology. 2004;62:1443.PubMedCrossRefPubMedCentralGoogle Scholar
  73. 73.
    Shaffer DN, Drevets DA, Farr RW. Listeria monocytogenes rhombencephalitis with cranial-nerve palsies: a case report. West Virginia Med J. 1998;94:80–3.Google Scholar
  74. 74.
    Shaw ML, Stone KL, Colangelo CM, Gulcicek EE, Palese P. Cellular proteins in influenza virus particles. PLoS Path. 2008;4PubMedCrossRefPubMedCentralGoogle Scholar
  75. 75.
    Shilo S, Wiener-Well Y, Korn-Lubetzki I. Varicella Zoster virus cerebellitis without a rash in an immunocompetent 85-year-old patient. Neurologist. 2015;20:44–5.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Shroff S, Kamiya-Matsuoka C, Woodman K. An unusual cause of cerebellar ataxia in an immunocompromised elderly patient. J Neurol Sci. 2014;340:218–20.PubMedCrossRefPubMedCentralGoogle Scholar
  77. 77.
    Sicard A, Yvon M, Timchenko T, Gronenborn B, Michalakis Y, Gutierrez S, Blanc S. Gene copy number is differentially regulated in a multipartite virus. Nat Commun. 2013;4:2248.PubMedCrossRefPubMedCentralGoogle Scholar
  78. 78.
    Spurgers KB, Alefantis T, Peyser BD, Ruthel GT, Bergeron AA, Costantino JA, Enterlein S, Kota KP, Boltz RCD, Aman MJ, DelVecchio VG, Bavari S. Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen. Mol Cell Proteomics. 2010;9:2690–703.PubMedCrossRefPubMedCentralGoogle Scholar
  79. 79.
    Srinivasan J, Ooi WW. Successful treatment of histoplasmosis brain abscess with voriconazole. Arch Neurol. 2008;65:666–7.PubMedCrossRefPubMedCentralGoogle Scholar
  80. 80.
    Starkey J, Moritani T, Kirby P. MRI of CNS fungal infections: review of aspergillosis to histoplasmosis and everything in between. Clin Neuroradiol. 2014;24:217–30.PubMedCrossRefPubMedCentralGoogle Scholar
  81. 81.
    Stegen C, Yakova Y, Henaff D, Nadjar J, Duron J, Lippe R. Analysis of virion-incorporated host proteins required for herpes simplex virus type 1 infection through a RNA interference screen. PLoS One. 2013;8:e53276.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Strafela P, Vizjak A, Vizjak A, Mraz J, Mraz J, Mlakar J, Mlakar J, Pizem J, Pizem J, Tul N, Tul N, Zupanc TA, Ta Z, Popovic M, Popovic M. Zika virus-associated micrencephaly: a thorough description of neuropathologic findings in the fetal central nervous system. Arch Pathol Lab Med. 2016;141:73–81.PubMedCrossRefPubMedCentralGoogle Scholar
  83. 83.
    Syrbe S, Merkenschlager A, Bernhard MK, Grosche J, Liebert UG, Hirsch W, Hartig W. Opsoclonus-myoclonus syndrome after adenovirus infection. Springerplus. 2015;4:636.PubMedCrossRefPubMedCentralGoogle Scholar
  84. 84.
    Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010;9:425–37.PubMedCrossRefPubMedCentralGoogle Scholar
  85. 85.
    Tang Y, Suddarth B, Du X, Matsumoto JA. Reversible diffusion restriction of the middle cerebellar peduncles and dentate nucleus in acute respiratory syncytial virus cerebellitis: a case report. Emerg Radiol. 2014;21:89–92.PubMedCrossRefPubMedCentralGoogle Scholar
  86. 86.
    Tavakoli NP, Wang H, Dupuis M, Hull R, Ebel GD, Gilmore EJ, Faust PL. Brief report: fatal case of deer tick virus encephalitis. New Engl J Med. 2009;360:2099–107.PubMedCrossRefPubMedCentralGoogle Scholar
  87. 87.
    Thompson MJ, Gowdie PJ, Kirkwood CD, Doherty RR, Fahey M. Rotavirus cerebellitis: new aspects to an old foe? Pediatr Neurol. 2012;46:48–50.PubMedCrossRefPubMedCentralGoogle Scholar
  88. 88.
    Uchida Y, Matsubara K, Morio T, Kawasaki Y, Iwata A, Yura K, Kamimura K, Nigami H, Fukaya T. Acute cerebellitis and concurrent encephalitis associated with parvovirus B19 infection. Pediatr Infect Dis J. 2012;31:427.PubMedCrossRefPubMedCentralGoogle Scholar
  89. 89.
    van der Linden V, Filho EL, Lins OG, van der Linden A, Aragao Mde F, Brainer-Lima AM, Cruz DD, Rocha MA, Sobral da Silva PF, Carvalho MD, do Amaral FJ, Gomes JA, Ribeiro de Medeiros IC, Ventura CV, Ramos RC. Congenital Zika syndrome with arthrogryposis: retrospective case series study. BMJ. 2016;354:i3899.PubMedCrossRefPubMedCentralGoogle Scholar
  90. 90.
    Vos MJ, Debets-Ossenkopp YJ, Claessen FAP, Hazenberg GJ, Heimans JJ. Cerebellar and medullar histoplasmosis. Neurology. 2000;54:1441.PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Weeratunga PN, Caldera HP, Gooneratne IK, Gamage R, Perera WS, Ranasinghe GV, Niraj M. Spontaneously resolving cerebellar syndrome as a sequelae of dengue viral infection: a case series from Sri Lanka. Pract Neurol. 2014;14:176–8.PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Withana M, Rodrigo C, Chang T, Karunanayake P, Rajapakse S. Dengue fever presenting with acute cerebellitis: a case report. BMC Res Notes. 2014;7:125.PubMedCrossRefPubMedCentralGoogle Scholar

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Medical Microbiology and Infectious DiseasesUniversity of ManitobaWinnipegCanada
  2. 2.Manitoba Centre for Proteomics and Systems BiologyWinnipegCanada

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