Metal Allergy pp 227-246 | Cite as

Prevention of Metal Exposure: Chelating Agents and Barrier Creams

  • Manohar Mahato
  • Nicholas E. Sherman
  • N. Kiran Kumar Mudnakudu
  • Nitin Joshi
  • Elisabeth Briand
  • Jeffrey M. Karp
  • Praveen Kumar Vemula


Metals are a group of elements which are ubiquitous in modern life. They are used in the fields of cosmetics, water purification, medicine, paint, food products, pesticides, and almost innumerable others. As the use of metals has increased in recent decades, so has human exposure to these elements. Metals such as mercury, lead, arsenic, nickel, and others have been implicated in negatively affecting human homeostasis by causing chronic inflammatory diseases, among other serious conditions. Both acute and chronic metal toxicity in vital organs could arise from local or systemic exposure to numerous metals. Although some metals have health benefits, overaccumulation of metals in body tissues can result in deleterious, toxic effects. Most exposure to metals occurs via cutaneous, inhalation, or oral routes. At the highest risk of negative effects of exposure are pregnant women and children. To ameliorate or prevent the toxic effects of metals, chelating agents and barrier creams are used widely in medical practice today. In this chapter, we will discuss preventing metal toxicity from overexposure via chelation therapy and skin barrier creams.



J.M.K., P.K.V, and E.B. hold equity in Skintifique, a company that has developed a proprietary nickel chelation technology and is commercializing products derived from this technology. E.B. is also an employee of Skintifique. J.M.K. and P.K.V. may benefit financially from Skintifique commercial sales of these products if the corresponding IP is licensed or optioned. The interests of J.M.K. and P.K.V. were reviewed and are subjected to a management plan overseen by their institutions in accordance with their conflict of interest policies.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Manohar Mahato
    • 1
  • Nicholas E. Sherman
    • 2
  • N. Kiran Kumar Mudnakudu
    • 1
  • Nitin Joshi
    • 2
  • Elisabeth Briand
    • 3
  • Jeffrey M. Karp
    • 3
    • 4
  • Praveen Kumar Vemula
    • 1
    • 5
  1. 1.Institute for Stem Cell Biology and Regenerative Medicine (inStem)BangaloreIndia
  2. 2.Department of Medicine, Division of Engineering in MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Skintifique R&DParisFrance
  4. 4.Harvard-MIT Division of Health Science and TechnologyCambridgeUSA
  5. 5.Ramalingaswami Re-Entry Fellow, Department of BiotechnologyGovernment of IndiaNew DelhiIndia

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