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State-of-the-Art in Tissue-Engineered Heart Repair

  • Buntaro Fujita
  • Malte Tiburcy
  • Stephan Ensminger
  • Wolfram-Hubertus ZimmermannEmail author
Chapter
  • 489 Downloads
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol., volume 4)

Abstract

Heart muscle restoration with in vitro engineered tissue constructs is an exciting and rapidly advancing field. Feasibility, safety, and efficacy data have been obtained in animal models. First clinical trials are on the way to explore the therapeutic utility of cell-free and non-contractile cell-containing grafts. Engineering of contractile patches according to current good manufacturing practice (cGMP) for bona fide myocardial re-muscularization and scalability to address clinical demands remains challenging. Proof-of-concept for solutions to address obvious technical hurdles exists, and it can be anticipated that the first generation of clinically applicable engineered heart muscle (EHM) grafts will become available in the near future. Foreseeable, but likely manageable risks include arrhythmia induction and teratoma formation. Remaining biomedical challenges pertain to the requirement of immune suppression and the strategic approach to optimize immune suppression without subjecting the target patient population to an unacceptable risk. This chapter summarizes the current state of tissue-engineered heart repair with a special emphasis on knowledge gained from in vitro and in vivo studies as well as issues pertaining to transplant immunology and cGMP process development.

Notes

Acknowledgments

The authors are supported by the ADUMED foundation (B.F.), the German Research Foundation (DFG ZI 708/10-1, SFB 1002 TP C04/S, SFB 937 A18, IRTG 1816; M.T., W.H.Z.), the Foundation Leducq (W.H.Z.), and the German Federal Ministry for Science and Education (BMBF FKZ 13GW0007A [BMBF/CIRM ETIII Award] and DZHK; W.H.Z.).

Compliance with Ethical Standards

Conflict of Interest

W.H.Z is cofounder and advisor of Repairon GmbH.

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.

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Authors and Affiliations

  • Buntaro Fujita
    • 1
    • 2
    • 3
  • Malte Tiburcy
    • 4
    • 2
  • Stephan Ensminger
    • 3
  • Wolfram-Hubertus Zimmermann
    • 4
    • 2
    Email author
  1. 1.Institute of Pharmacology and ToxicologyUniversity Medical Center GöttingenGöttingenGermany
  2. 2.DZHK (German Center for Cardiovascular Research), Partner Site GöttingenGöttingenGermany
  3. 3.Department of Thoracic and Cardiovascular SurgeryHeart and Diabetes Center NRW, Ruhr-University BochumBad OeynhausenGermany
  4. 4.Institute of Pharmacology and ToxicologyUniversity Medical Center Göttingen, Georg-August UniversityGöttingenGermany

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