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Tumor Treatment

  • Srikanth R. Boddu
  • Thomas W. Link
  • Athos Patsalides
Chapter

Abstract

The role of endovascular therapy in tumor management has significantly increased over the past decade as a result of improved technology, better understanding of tumor pathology, and evolution of chemotherapy regimens. The role of endovascular therapy has a broad spectrum in tumor management, from emergency treatment of a life-threatening carotid blowout to elective preoperative tumor embolization. The multifaceted role of tumor embolization ranges from adjuvant treatment in meningiomas and diffuse pontine gliomas to primary treatment in retinoblastoma, with selective ophthalmic artery chemosurgery.

Through knowledge of intracranial and extracranial anastomotic pathways, understanding of vascular anatomy, identification of high-flow shunts within the tumor, and awareness of personal and procedural limitations all help to minimize adverse outcomes. Utilizing cerebral hemispheric dose calculations and appropriate catheter placement and injection techniques is vital to enable an increase in local dosage using IA chemotherapy and improve bioavailability, with neurotoxicity comparable to conventional intravenous chemotherapy. With the developments in technology for early tumor detection and radio isotope labeling of target tumor cells based on angioneogenesis and tumor-specific characteristics, IA chemotherapy is evolving as a promising selective target tumor treatment.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Srikanth R. Boddu
    • 1
  • Thomas W. Link
    • 1
  • Athos Patsalides
    • 1
  1. 1.Division of Interventional Neuroradiology, Department of Neurological SurgeryWeill Cornell Medical Center/New York Presbyterian HospitalNew YorkUSA

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