MRI Texture-Based Classification of Dystrophic Muscles. A Search for the Most Discriminative Tissue Descriptors
The study assesses the usefulness of various texture-based tissue descriptors in the classification of canine hindlimb muscles. Experiments are performed on T2-weighted Magnetic Resonance Images (MRI) acquired from healthy and Golden Retriever Muscular Dystrophy (GRMD) dogs over a period of 14 months. Three phases of canine growth and/or dystrophy progression are considered. In total, 39 features provided by 8 texture analysis methods are tested. Features are ranked according to their frequency of selection in a modified Monte Carlo procedure. The top-ranked features are used in differentiation (i) between GRMD and healthy dogs at each phase of canine growth, and (ii) between three phases of dystrophy progression in GRMD dogs. Three classifiers are applied: Adaptive Boosting, Neural Networks, and Support Vector Machines. Small sets of selected features (up to 10) are found to ensure highly satisfactory classification accuracies.
KeywordsGolden Retriever Muscular Dystrophy (GRMD) Duchenne Muscular Dystrophy (DMD) Texture analysis Feature selection Classification MRI T2
This work was performed under the auspices of the European COST Action BM1304, MYO-MRI. It was also performed in the framework of the grant S/WI/2/2013 (Bialystok University of Technology), founded by the Polish Ministry of Science and Higher Education.
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