Peripheral Nerve Disorders



A nerve is composed of axon (neural tissue) and connective tissue. Each axon in myelinated nerve fibers is surrounded by the endoneurium. Groups of nerve fibers form fascicles, surrounded by the perineurium, and groups of fascicles are surrounded by the internal and external epineurium. Impairments of the peripheral nervous system (PNS) lead to peripheral neuropathies that could be whether acquired (traumatic, drug toxicity, infection, etc.) or inherited, due to genetic abnormalities.

Supplementary material

Video 41.1

A 4-year-old girl, with acute lymphoblastic leukemia (ALL), who developed toxicity following vincristine therapy (Fig. 41.3a, b). She could walk after 7 months, and the video, taken 9 months later, shows normal gait (MOV 17021 kb)

Video 41.2

Resuming normal gait in a 10-year-old boy who had Guillain-Barré syndrome a year ago. During the acute illness, he required ventilation for 22 days (AVI 2441 kb)

Video 41.3

An 11-year-old boy with peripheral nervous system vasculitis associated with Churg-Strauss syndrome (Fig. 41.9). The video shows the asymmetric involvement of the lower limbs with right foot drop and high steppage gait (MOV 1567 kb)

Video 41.4

High steppage gait, pes planus, and foot drop in 2.5-year-old twins who have CMT4A due to GDAP1 gene mutation (AVI 9962 kb)


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Pediatric Neurology, Department of Pediatrics, College of Medicine and King Khalid University HospitalKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Institute for Neuropathology, Uniklinik-RWTHAachenGermany

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