Predicting Embryo Developmental Potential and Viability Using Automated Time-Lapse Analysis (Eeva™ Test)

  • Lei Tan
  • Alice A. Chen
  • Shehua Shen


The objective of this chapter is to describe the development, validation, and practical application of the first noninvasive, embryo viability assessment tool that has been designed to meet clinical test criteria and proven to add critical information to the decision-making practices of clinical embryologists. In describing this novel test, we review the criteria for development and validation of a clinical test, assess the scientific underpinning of prediction using time-lapse imaging, and introduce new advances in automation enabled by state-of-the-art computer vision software.


Time-lapse imaging Automation Embryo development Embryo selection Noninvasive Algorithm Clinical test 



We gratefully acknowledge the physicians, embryologists, and patients who participated in the development and validation studies of the Eeva Test. We also thank the clinical trial experts, biology scientists, and computer vision engineers, for their technical contributions and insightful discussions.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Lei Tan
    • 1
  • Alice A. Chen
    • 2
  • Shehua Shen
    • 3
  1. 1.Celmatix, Inc.New YorkUSA
  2. 2.GRAIL, Inc.Menlo ParkUSA
  3. 3.Hernest Institute for Reproductive MedicineSunnyvaleUSA

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