GVHD Manifesting as Sicca Syndrome

  • Cecilia C. S. YeungEmail author
  • Howard M. Shulman


Sicca syndrome is a common condition that can develop in chronic GVHD (cGVHD) where the allogeneic donor immune system attacks the salivary and lacrimal glands causing xerostomia and xerophthalmia. In this chapter, we present a case of a patient with absolute xerophthalmia and oral mucositis. We will discuss how GVHD presents clinically and pathologically in the salivary glands, lacrimal glands, and conjunctiva.


Sicca syndrome Salivary glands Lacrimal glands Xerostomia Xerophthalmia Chronic GVHD Conjunctiva 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Clinical Research DivisionFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of PathologyUniversity of Washington School of MedicineSeattleUSA
  3. 3.Pathology SectionSeattle Cancer Care AllianceSeattleUSA

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