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Dermatologic Manifestations Among Transplant Recipients

  • Lídice Dufrechou
  • Alejandra Larre Borges
Chapter

Abstract

Organ transplantation constitutes a life-saving intervention for persons with end-stage organ disease. Long-term immunosuppressant therapy is essential for graft survival but results in reduced immunosurveillance, which leads to an increased risk of complications. A variety of dermatologic manifestations including a large increase in nonmelanoma skin cancers have been reported in this population. The purpose of this chapter is to describe the clinical spectrum of cutaneous manifestations in solid transplant recipients regarding epidemiology, etiopathogenesis, clinical presentation, and therapeutic approach.

Keywords

Transplant Recipients Cutaneous Skin Immunosuppression 

Notes

Glossary

Antibiogram

A record of the susceptibility of specific pathogenic bacteria to antibiotics. Antibiograms are often taken into account to define a rational selection of an antimicrobial therapy.

Antimetabolites

Drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. They affect DNA synthesis by acting as a substitute for the actual metabolites that would be used in the normal metabolism.

Calcineurin inhibitors

Suppress the immune system by preventing interleukin-2 (IL-2) production in T cells.

Cryotherapy

Treatment using low temperature for the removal of some skin lesions by freezing them. The most common product used by doctors is liquid nitrogen.

Mohs micrographic surgery

Microscopically controlled surgery used to treat common types of skin cancer. During the surgery, after each removal of tissue and while the patient waits, the tissue is examined for cancer cells. This examination informs the decision for additional tissue removal. Mohs surgery is one of the many methods of obtaining complete margin control during removal of a skin cancer.

mTOR inhibitors

mTOR inhibitors are a class of drugs that inhibit the mTOR, which is a serine/threonine-specific protein kinase belonging to the family of phosphatidylinositol 3-kinase (PI3K)-related kinases (PIKKs). mTOR regulates cellular metabolism, growth, and proliferation.

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Further Information Can Be Found at the Following Internet Addresses

  1. Committee for the Care of Immunosuppressed Patients of the Dermatologic Oncology Working Group: www.ado-homepage.de.
  2. German Transplantation Society (Deutsche Transplan​tationsgesellschaft e.V., DTG): www.d-t-g-online.de.
  3. German network of dermatologists in private practice specializing in the care of organ-transplant recipients (the ONKODERM e.V. network): www.onkoderm.de.
  4. German Dialysis and Renal Transplantation Board (Kuratorium für Dialyse und Nierentransplantation e.V., KfH): www.kfh-dialyse.de/kfh/index.html.
  5. German Association of Organ-Transplant Recipients (Bundesverband der Organtransplantierten e.V., BDO): www.bdo-ev.de.
  6. German Working Group for Nursing Care in Transplantation (Arbeitskreis AKTX-Pflege e.V.): www.aktxpflege.de.
  7. Skin Care in Organ Transplant Patients Network, Europe: www.SCOPEnetwork.org.

Copyright information

© Springer International Publishing Switzerland 2018

Authors and Affiliations

  1. 1.Adjudant Professor, UDELAR, Hospital de ClínicasCátedra de Dermatología, Unidad de Lesiones PigmentadasMontevideoUruguay
  2. 2.Assistant Professor, UDELAR, Hospital de ClínicasCátedra de Dermatología, Unidad de Lesiones PigmentadasMontevideoUruguay

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