Dermatologic Manifestations in Renal Failure

  • Lídice Dufrechou VarelaEmail author
  • Alejandra Larre Borges
  • Andrea Nicola Centanni


Chronic renal failure (CRF) is a major public health problem worldwide. Patients living with CRF are considered to follow a chronic inflammatory state due to multiple factors. From a dermatologic point of view, there is a high frequency of dermatoses associated with this condition. They can be divided into specific and nonspecific, the latter having the highest prevalence, but all of them show a significant impact on the quality of life of affected patients. Xerosis, bruising, and itching are ubiquitous in this population and are considered multifactorial. Among them, xerosis, pale skin and itching are the most prevalent ones. On the other hand, specific dermatoses are classified as acquired perforating disorders, bullous dermatoses, calcification disorders, nephrogenic systemic fibrosis, specific nail changes, and uremic frost. Most skin disorders are benign and do not affect the course of CRF. On several occasions skin disorders can predict the initiation of a renal replacement plan, or may be precipitated by it.


Chronic renal failure Hemodialysis Nonspecific dermatoses Specific dermatoses 




Alteration of the color of the skin.


Enlargement of the breast in the males, caused by an excess of estrogens.


Excessively large tongue.


Pathologic processes of the microvessels.

Pruritogenic substances 

Substances capable of causing pruritus (itching).

Raynaud’s phenomenon 

Abrupt onset of digital paleness followed by cyanosis and erythema in response to cold.

Teratogenic effect 

Capacity of some substances of generate physical defects in the developing embryo.


Porphyrins produced by oxidation of uroporphyrinogen, which can be excreted in excess in the urine in the context of porphyrias.


Decreased salivary flow (dry mouth).


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Copyright information

© Springer International Publishing Switzerland 2018

Authors and Affiliations

  • Lídice Dufrechou Varela
    • 1
    Email author
  • Alejandra Larre Borges
    • 2
  • Andrea Nicola Centanni
    • 3
  1. 1.Assistant Professor of DermatologyHospital de Clínicas “Dr. Manuel Quintela”de MontevideoUruguay
  2. 2.Adjunct Professor of DermatologyHospital de Clìnicas “Dr. Manuel Quintela”de MontevideoUruguay
  3. 3.Hospital de Clínicas “Dr. Manuel Quintela”MontevideoUruguay

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