Abstract
Tobacco smoking, one of the main modifiable risk factors for mortality, is associated with cutaneous neoplasias and cutaneous aging, besides worsening of the postsurgical scarring process. It is also involved with the pathogenesis and the worsening of some dermatoses, such as Buerger’s disease, lupus, psoriasis, and hidradenitis suppurativa. Alcoholism is a chronic, progressive, and lethal disease that leads to multiple organ dysfunction and skin manifestations associated with endocrinologic changes, with nutritional deficiencies and signs of hepatopathy. Alcoholism is associated with the triggering or worsening of dermatoses, such as psoriasis, porphyria, seborrheic dermatitis, rosacea, urticaria, contact dermatitis, and eczema. Advice to patients on quitting smoking and drinking should be part of the routine general directions about general health and the skin health. Cocaine, one of the world’s oldest drugs, causes euphoria accompanied by serious side effects including cardiac disorders, skin necrosis, and nasal septum perforation, among others. This chapter discusses the main manifestations of tobacco smoking, alcoholism, and drug addiction (particularly cocaine use, also when mixed with adjuvant drugs such as levamisole).
References
Metelitsa AI, Lauzon GJ. Tobacco and the skin. Clin Dermatol. 2010;28(4):384–90.
Just-Sarobé M. Smoking and the skin. Actas Dermo-Sifiliograficas (English Edition). 2008;99(3):173–84.
Ortiz A, Grando SA. Smoking and the skin. Int J Dermatol. 2012;51(3):250–62.
Böckle BC, Sepp NT. Smoking is highly associated with discoid lupus erythematosus and lupus erythematosus tumidus: analysis of 405 patients. Lupus. 2015;24(7):669–74.
Chasset F, et al. Influence of smoking on the efficacy of antimalarials in cutaneous lupus: a meta-analysis of the literature. J Am Acad Dermatol. 2015;72(4):634–9.
Prens E, et al. Pathophysiology of hidradenitis suppurativa: an update. J Am Acad Dermatol. 2015;73(5):S8–S11.
Brans R, et al. Association between tobacco smoking and prognosis of occupational hand eczema: a prospective cohort study. Br J Dermatol. 2014;171(5):1108–15.
Lukács J, Schliemann S, Elsner P. Association between smoking and hand dermatitis–a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2015;29(7):1280–4.
Gill JF, Yu SS, Neuhaus IM. Tobacco smoking and dermatologic surgery. J Am Acad Dermatol. 2013;68(1):167–72.
Bologna J, Jorizzo J, Rapini RP. Dermatology. 2nd ed. London: Ed. Mosby; 2010.
Liu SW, Lien MH, Fenske NA. The effects of alcohol and drug abuse on the skin. Clin Dermatol. 2010;28(4):391–9.
Dinis-Oliveira RJ, et al. Clinical and forensic signs related to ethanol abuse: a mechanistic approach. Toxicol Mech Methods. 2014;24(2):81–110.
Rehm J, et al. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet. 2009;373(9682):2223–33.
Smith KE, Fenske NA. Cutaneous manifestations of alcohol abuse. J Am Acad Dermatol. 2000;43(1):1–18.
Besemer F, Pereira AM, Smit JWA. “Alcohol-induced Cushing syndrome”. Hypercortisolism caused by alcohol abuse. Neth J Med. 2011;69:318–23.
Mukamal KJ. Alcohol consumption and self-reported sunburn: a cross-sectional, population-based survey. J Am Acad Dermatol. 2006;55(4):584–9.
Wong JW, Harris KL, Powell D. Alcohol urticaria syndrome. Dermatitis. 2011;22(6):350–4.
Wolverton W, Gada S. Systemic contact dermatitis to ethanol. J Allergy Clin Immunol. (In practice). 2013;1(2):195.
Lübbe J, Milingou M. Tacrolimus Oinment, Alcohol, and Facial Flushing. N Eng J Med 2004;351:2740.
Fink B, Landthaler M, Hafner C. Skin alterations due to illegal drug abuse. JDDG: J Dtsch Dermatol Ges. 2011;9(8):633–9.
Bergstrom KG. Cutaneous clues to drug addiction. J Drugs Dermatol. 2008;7(3):303–5.
United Nations Office on Drugs and Crime, World Drug Report 2015 (United Nations publication, Sales No. E.15.XI.6).
Michaud K, Grabherr S, Shiferaw K, Doenz F, Augsburger M, Mangin P. Acute coronary syndrome after levamisole-adulterated cocaine abuse. J Forensic Legal Med. 2014;21:48–52. PubMed PMID: 24365689
Jenkins J, Babu K, Hsu-Hung E, Robinson-Bostom L, Kroumpouzos G. ANCA-positive necrotizing vasculitis and thrombotic vasculopathy induced by levamisole-adulterated cocaine: a distinctive clinicopathologic presentation. J Am Acad Dermatol. 2011;65(1):e14–6. PubMed PMID: 21679797.
Chung C, Tumeh PC, Birnbaum R, Tan BH, Sharp L, McCoy E, et al. Characteristic purpura of the ears, vasculitis, and neutropenia – a potential public health epidemic associated with levamisole-adulterated cocaine. J Am Acad Dermatol. 2011;65(4):722–5. PubMed PMID: 21658797. Pubmed Central PMCID: 4000158.
Streicher JL, Swerlick RA, Stoff BK. Cocaine abuse and confidentiality: a case of retiform purpura in an adolescent patient. J Am Acad Dermatol. 2014;70(6):1127–9. PubMed PMID: 24831315.
Lee KC, Ladizinski B, Federman DG. Complications associated with use of levamisole-contaminated cocaine: an emerging public health challenge. Mayo Clin Proc. 2012;87(6):581–6.
Chawdhary K, Parke A. Levamisole-induced vasculitis with renal involvement. Conn Med. 2015;79(6):343–6. PubMed PMID: 26263714.
Dy I, Pokuri V, Olichney J, Wiernik P. Levamisole-adulterated in cocaine causing agranulocytosis, vasculopathy, and acquired protein S deficiency. Ann Hematol. 2012;91(3):477–8. PubMed PMID: 21773730.
Caldwell KB, Graham OZ, Arnold JJ. Agranulocytosis from levamisole-adulterated cocaine. J Am Board Fam Med: JABFM. 2012;25(4):528–30. PubMed PMID: 22773721.
Jadhav P, Tariq H, Niazi M, Franchin G. Recurrent thrombotic vasculopathy in a former cocaine user. Case Rep Dermatol Med. 2015;2015:763613. PubMed PMID: 26793396. Pubmed Central PMCID: 4697073.
Baptiste GG, Alexopoulos AS, Masud T, Bonsall JM. Systemic levamisole-induced vasculitis in a cocaine user without cutaneous findings: a consideration in diagnosis. Case Rep Med. 2015;2015:547023. PubMed PMID: 26635879. Pubmed Central PMCID: 4618334.
Botelho ED, Cunha RB, Campos AFC, Maldanera AO. Chemical profiling of cocaine seized by Brazilian federal police in 2009–2012: major components. J Braz Chem Soc. 2014;25(4):611–8.
Strazzula L, Brown KK, Brieva JC, Camp BJ, Frankel HC, Kissin E, et al. Levamisole toxicity mimicking autoimmune disease. J Am Acad Dermatol. 2013;69(6):954–9. PubMed PMID: 24075227.
Tichauer et al. Levamisole-induced ANCA vasculitis and cutaneous necrosis. http://www.ePlasty.com, Interesting Case, October 17, 2014.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Glossary
- Acetylcholine
-
Neurotransmitter released by cholinergic neurons responsible for muscle contraction, learning, and memory, whose action is mediated by nicotinic and muscarinic receptors found at the neuromuscular junctions in the central and peripheral nervous system.
- Acneiform eruption
-
Dermatosis related to the development of papules and follicular pustules, with or without comedones, connected to predisposing factors or medicines, located in sites that do not usually show acne, or occurring in life stages other than adolescence.
- Carboxyhemoglobin
-
Molecule of carbon monoxide linked to a molecule of hemoglobin. Its development is associated with carbon monoxide toxicity.
- Carcinogen
-
A substance, situation, or exposition that can damage the genetic material (DNA), thus initiating or stimulating cancer development.
- Cheilitis
-
Lip dermatosis resulting from different causes that manifests as erythemas, scaling, vesicles, fissures, tumefaction, nodules, and so forth.
- Comedones
-
Solid development in the pilosebaceous follicles resulting from retained sebum produced by the gland due to acro-infundibulum obliteration by focal keratosis.
- Cytolytic
-
Related to cell destruction (cytolysis).
- Discoid
-
Semiologic description of lesion feature shaped like a disc.
- Glossitis
-
Alterations of the tongue mucosa caused by poor nutrition, infections, and physical, chemical, or drug-induced irritation that are manifested by partial or total loss of the filiform papillae, and smooth and red tongue.
- Gynecomastia
-
Increased breast tissue, unilaterally or bilaterally, in men.
- Jaundice
-
Yellow color of skin, mucosa, and sclera caused by hyperbilirubinemia.
- Keratinization
-
Final phase of the keratinocyte differentiation whereby keratin is formed.
- Metalloproteinases
-
Zinc-dependent proteinases that show cleavage activity (gelatinolytic) of the matrix and angiogenic and inflammatory activities, synthesized by many cells including fibroblasts and leukocytes.
- Mutagenic
-
Physical, chemical, or biological agent which can cause mutation if exposed to one cell, i.e., damage to the DNA that is not repaired and is passed on to the next generations.
- Neovascularization
-
Development of new blood vessels. This process can be physiologic or pathologic.
- Nummular
-
Semiologic description of lesion feature as “rounded, resembling coin.”
- Pathognomonic
-
The characteristic and proper sign of a disease.
- Plethoric
-
Red coloration through vascular engorgement in polycythemic patients; increased blood volume.
- Rhytids
-
Skin lines and depressions resulting from facial, neck, hand, and arm aging, commonly known as wrinkles.
- Steatosis
-
Tissue fat accumulation.
- Stomatitis
-
Dermatosis of mucosa of the buccal cavity of multiple etiology, such as infections and nicotine.
- Telangiectasia
-
Dilation of dermal small blood vessels.
Rights and permissions
Copyright information
© 2018 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Bonamigo, R.R., Brutti, C., Capelletti, T., Duquia, R.P., Keiserman, M.W. (2018). Smoking, Alcoholism, and Use of Illicit Drugs. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_39
Download citation
DOI: https://doi.org/10.1007/978-3-319-33919-1_39
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-33917-7
Online ISBN: 978-3-319-33919-1
eBook Packages: MedicineMedicine (R0)