Aphthosis is an inflammatory disease characterized by painful recurrent oral ulcerations. The cause of aphthosis is unknown, and several studies indicate a role for the immune system in the physiopathogenesis of this disease. Oral lesions appear mainly on nonkeratinized mucosa as painful, regular, round or oval ulcers covered with a gray pseudomembrane and surrounded by an erythematous halo. The diagnosis of aphthosis is mainly established on clinical grounds. Treatment depends on the severity, recurrence rate, and response to previous therapies.
KeywordsRecurrent aphthous stomatitis Oral ulcers Aphthosis
Synonymous to aphthosis. Also used as the description of the individual ulcer of the disease.
A disease characterized by bursts of oral ulcerations, accompanied or not by ulcerations elsewhere (usually genitals) and systemic complaints.
Diaminodiphenyl sulfone (DDS), an antibiotic used in the treatment of leprosy and as an anti-inflammatory drug in several noninfectious skin diseases.
One of several clinical types of aphthae, i.e., one that presents as multiple subintrant small ulcerations.
Any lesion characterized by loss of the oral epithelium.
An immunomodulatory drug that is the prototype of the thalidomide class of drugs.
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