Embryology of the Great Vessels

  • Maria IlinaEmail author
  • Stuart Lilley


The vascular system appears in the middle of week 3 of development from fixed primitive angiogenic cells which are mesodermal in origin. The first arteries to appear are the right and left primitive aortae which appear as a continuation of the endocardial heart tubes. The primitive aortae curve dorsally in the first pharyngeal arch, around the anterior part of the foregut, and then continue dorsally as the two dorsal aortae.

Recommended Reading

  1. Frescura C, Thiene G. The new concept of univentricular heart. Front Pediatr. 2014;2(62):1–17.Google Scholar
  2. Samanek M, Slavik Z, Zborilova B, Hrobonova V, Voriskova M, Skovranek J. Prevalence, treatment, and outcome of heart disease in live-born children: a prospective analysis of 91823 live-born children. Pediatr Cardiol. 1989;10(4):205–11.CrossRefGoogle Scholar
  3. Kitchiner DJ, Jackson M, Walsh K, Peart I, Arnold R. Incidence and prognosis of congenital aortic valve stenosis in Liverpool (1960–1990). Br Heart J. 1993;69(1):71–9.CrossRefGoogle Scholar
  4. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890–900.CrossRefGoogle Scholar
  5. Bu’Lock F, Shebani S, Eltayb H, Peek G, Khare M, Mouse H. Effect of changes to UK fetal cardiac screening protocols across the spectrum of congenital heart disease requiring intervention in the first year of life. Ultrasound in Obstetrics and Gynecology, 9–12 Sep 2012, Copenhagen, Denmark.Google Scholar
  6. MacDonald MJ, Hanley FL. Pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals. In: Yuh DD, Vricella LA, Yang SC, Doty JR, editors. Johns Hopkins manual of cardiothoracic surgery. New York, NY: McGraw-Hill; 2007. p. 1141–8. Chapter 61.Google Scholar
  7. Lupo PJ, Langlois PH, Mitchell LE. Epidemiology of Ebstein anomaly: prevalence and patterns in Texas, 1999–2005. Am J Med Genet A. 2011;155A(5):1007–14.CrossRefGoogle Scholar
  8. Anderson R. Interatrial communication [Internet]. 2007 [cited 04/01/2016]. Available from
  9. Ballerini L. Truncus arteriosus [Internet]. 2005 [cited 04/01/2016]. Available from:
  10. Park MK. Park’s the pediatric cardiology handbook. 5th ed: Elsevier Saunders; 2016.Google Scholar
  11. Fontan F, Baudet E. Surgical repair of tricuspid atresia. Thorax. 1971;26(3):240–8.CrossRefGoogle Scholar
  12. Anderson RH, Baker EJ, Penny DJ, Redington AN, Rigby ML, Wernovsky G, editors. Paediatric cardiology. 3rd ed. Philadelphia, PA: Churchill Livingstone/Elsevier; 2010.Google Scholar
  13. Freedom RM, Yoo S-J, Mikailian H, Williams WG. The natural and modified history of congenital heart disease. 1st ed. New York: Blackwell publishing, Inc/Futura Division; 2004.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Queen Elizabeth University HospitalGlasgowUK

Personalised recommendations