• Aaron Jamison
  • Gerard McGowan


Development of the eye starts around day 22 (embryo is 2 mm in length). While the neural folds are fusing rostrally and caudally to form the neural tube, two shallow grooves, or ‘optic pits’, form from neural ectoderm in the neural plate. The neural folds in this area fuse soon after, forming the primordial diencephalon. Continued evagination of the optic pits results in the formation of two symmetrical hollow hemispherical outgrowths on the lateral sides of the primordial forebrain—the primary optic vesicles. Over the next few days, the optic vesicles enlarge and become surrounded by mesenchymal cells, likely derived from the cephalic neural crest.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Aaron Jamison
    • 1
  • Gerard McGowan
    • 1
  1. 1.Tennent Institute of OphthalmologyGartnavel General HospitalGlasgowUK

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