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Surgery for Parkinson's Disease pp 159–172Cite as

DBS Innovations in the Near Future?

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Abstract

Advancement in deep brain stimulation (DBS) technology through the identification and development of new stimulation targets, stimulation hardware, and programming methods continues to drive innovation in stimulation treatment. In addition to the well-established DBS targets of the subthalamic nucleus (STN), the globus pallidus interna (GPi), and the ventralis intermedius (VIM) thalamus used in the treatment of Parkinson’s disease (PD), emerging targets that have recently gained attention include the zona incerta (ZI), subthalamic white matter fibers, pedunculopontine nucleus (PPN), and substantia nigra reticulata (SNr). Advances in electrode design and options in closed-loop DBS systems show promise in tailoring stimulation to individual patient preferences. Innovations in programming parameters, including interleaved stimulation and burst stimulation, can serve to optimize the balance between adequate energy delivery and reducing recharging burden. The vast future potential of these technologies is instrumental in optimizing patient outcomes and expanding potential DBS indications for years to come.

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Authors and Affiliations

  1. Department of Neurosurgery, Albany Medical Center, Albany, NY, USA

    Vignessh Kumar & Julie G. Pilitsis

  2. Department of Neurosurgery, Cleveland Clinic, Neurologic Institute, Cleveland, OH, USA

    Andre G. Machado

  3. Cleveland Clinic, Neurologic Institute, Center for Neurological Restoration, Cleveland, OH, USA

    Andre G. Machado

  4. Department of Neurology, University of Florida, Gainesville, FL, USA

    Adolfo Ramirez-Zamora

  5. Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY, USA

    Julie G. Pilitsis

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  1. Vignessh Kumar
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  1. Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ, USA

    Robert R. Goodman

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Kumar, V., Machado, A.G., Ramirez-Zamora, A., Pilitsis, J.G. (2019). DBS Innovations in the Near Future?. In: Goodman, R. (eds) Surgery for Parkinson's Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-23693-3_12

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