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Fluorescence Imaging Systems (PDE, HyperEye Medical System, and Prototypes in Japan)

  • Takeaki Ishizawa
  • Norihiro KokudoEmail author
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Abstract

Clinical application of fluorescence-guided surgery using indocyanine green has been expanded with the advances in imaging techniques and distribution of fluorescence imaging systems on the market. We describe the history of the development and characteristics of fluorescence imaging systems for clinical use that are currently available in Japan: PDE®, HyperEye Medical System, and other prototype laparoscopic imaging systems.

Keywords

Fluorescence imaging Imaging system Indocyanine green Navigation surgery 

Notes

Financial Disclosure: The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, and royalties. No writing assistance was used in the production of this manuscript.

Funding/Support: This work was supported by grants from the Takeda Science Foundation, the Ministry of Education, Culture, Sports, Science, Technology of Japan, and the Ministry of Health, Labour, and Welfare of Japan, and Global Leader Program for Social Design and Management.

Supplementary material

Video 7.1

Identification of primary and secondary liver cancer during hepatectomy by the series of PDE® systems (WMV 76,462 kb)

Video 7.2

Intraoperative real-time identification of disseminated nodules caused by percutaneous radiofrequency ablation for hepatocellular carcinoma using the HyperEye Medical System (WMV 63,227 kb)

Video 7.3

Fluorescence cholangiography using the HyperEye Medical System during donor right hepatectomy (WMV 61,351 kb)

References

  1. 1.
    Ishizawa T, Kokudo N. The beginning of a new era of digestive surgery guided by fluorescence imaging. Liver Cancer. 2014;3:6.PubMedCentralCrossRefPubMedGoogle Scholar
  2. 2.
    Aoki T, Yasuda D, Shimizu Y, Odaira M, Niiya T, Kusano T, et al. Image-guided liver mapping using fluorescence navigation system with indocyanine green for anatomical hepatic resection. World J Surg. 2008;32:1763–7.CrossRefPubMedGoogle Scholar
  3. 3.
    Mitsuhashi N, Kimura F, Shimizu H, Imamaki M, Yoshidome H, Ohtsuka M, et al. Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery. J Hepatobiliary Pancreat Surg. 2008;15:508–14.CrossRefPubMedGoogle Scholar
  4. 4.
    Ishizawa T, Tamura S, Masuda K, Aoki T, Hasegawa K, Imamura H, et al. Intraoperative fluorescent cholangiography using indocyanine green: a biliary road map for safe surgery. J Am Coll Surg. 2008;208:e1–4.CrossRefPubMedGoogle Scholar
  5. 5.
    Ishizawa T, Fukushima N, Shibahara J, Masuda K, Tamura S, Aoki T, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer. 2009;115:2491–504.CrossRefPubMedGoogle Scholar
  6. 6.
    Gotoh K, Yamada T, Ishikawa O, Takahashi H, Eguchi H, Yano M, et al. A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation. J Surg Oncol. 2009;100:75–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Shimizu A, et al. Identification of the lymphatic drainage pathways from the pancreatic head guided by indocyanine green fluorescence imaging during pancreaticoduodenectomy. Dig Surg. 2012;29:132–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Mihara M, Murai N, Hayashi Y, Hara H, Iida T, Narushima M, et al. Using indocyanine green fluorescent lymphography and lymphatic-venous anastomosis for cancer-related lymphedema. Ann Vasc Surg. 2012;278:e1–6.Google Scholar
  9. 9.
    Handa T, Katare RG, Nishimori H, Wariishi S, Fukutomi T, Yamamoto M, et al. New device for intraoperative graft assessment: HyperEye charge-coupled device camera system. Gen Thorac Cardiovasc Surg. 2010;58:68–77.CrossRefPubMedGoogle Scholar
  10. 10.
    Yamauchi K, Nagafuji H, Nakamura T, Sato T, Kohno N. Feasibility of ICG fluorescence-guided sentinel node biopsy in animal models using the HyperEye Medical System. Ann Surg Oncol. 2011;18:2042–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Kawaguchi Y, Ishizawa T, Masuda K, Sato S, Kaneko J, Aoki T, et al. Hepatobiliary surgery guided by a novel fluorescent imaging technique for visualizing hepatic arteries, bile ducts, and liver cancers on color images. J Am Coll Surg. 2011;212:e33–9.CrossRefPubMedGoogle Scholar
  12. 12.
    Nimura H, Narimiya N, Mitsumori N, Yamazaki Y, Yanaga K, Urashima M. Infrared ray electronic endoscopy combined with indocyanine green injection for detection of sentinel nodes of patients with gastric cancer. Br J Surg. 2004;91:575–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Kusano M, Tajima Y, Yamazaki K, Kato M, Watanabe M, Miwa M. Sentinel node mapping guided by indocyanine green fluorescence imaging: a new method for sentinel node navigation surgery in gastrointestinal cancer. Dig Surg. 2008;25:103–8.CrossRefPubMedGoogle Scholar
  14. 14.
    Harada K, Miwa M, Fukuyo T, Watanabe S, Enosawa S, Chiba T. ICG fluorescence endoscope for visualization of the placental vascular network. Minim Invasive Ther Allied Technol. 2009;18:1–5.CrossRefPubMedGoogle Scholar
  15. 15.
    Ishizawa T, Bandai Y, Ijichi M, Kaneko J, Hasegawa K, Kokudo N. Fluorescent cholangiography illuminating the biliary tree during laparoscopic cholecystectomy. Br J Surg. 2010;97:1369–77.CrossRefPubMedGoogle Scholar
  16. 16.
    Kudo H, Ishizawa T, Tani K, Harada N, Ichida A, Shimizu A, et al. Application of indocyanine-green fluorescence imaging for visualizing hepatic malignancy during laparoscopic surgery. Surg Endosc. 2014;28:2504.CrossRefPubMedGoogle Scholar
  17. 17.
    Ishizawa T, Zuker NB, Kokudo N, Gayet B. Positive and negative staining of hepatic segments by use of fluorescent imaging techniques during laparoscopic hepatectomy. Arch Surg. 2012;147:393–4.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Gastroenterological Surgery, Cancer Institute HospitalJapanese Foundation for Cancer ResearchKoto-kuJapan
  2. 2.Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of MedicineUniversity of TokyoBunkyo-kuJapan

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