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Plasma Membrane-Associated Sialidase Confers Cancer Initiation, Promotion and Progression

  • Taeko MiyagiEmail author
  • Kohta Takahashi
  • Kazuhiro Shiozaki
  • Kazunori Yamaguchi
  • Masahiro Hosono
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 842)

Abstract

Altered sialylation has been implicated in malignant properties of cancer cells. However, the detailed molecular mechanism remains uncertain. Our studies on mammalian sialidases have facilitated understanding of the molecular bases of aberrant sialylation related to malignancy. Among four types of sialidase so far identified in mammalian cells and tissues, the plasma membrane-associated sialidase NEU3, acting preferentially on gangliosides, has been found to be markedly upregulated in various human carcinomas, and involved in promotion of malignant phenotypes including cell migration, invasiveness and cell survival. NEU3 regulates various signaling pathways critical to cellular homeostasis, and its marked increase in cancer causes dysregulation of the physiological processes resulting in enhancement of tumor initiation, promotion, and progression.

Keywords

Sialidase Sialic acid Cancer Ganglioside Cell signaling 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Taeko Miyagi
    • 1
    Email author
  • Kohta Takahashi
    • 1
  • Kazuhiro Shiozaki
    • 2
  • Kazunori Yamaguchi
    • 3
  • Masahiro Hosono
    • 4
  1. 1.Cancer Glycosylation Research, Institute of Molecular Biomembrane and GlycobiologyTohoku Pharmaceutical UniversitySendaiJapan
  2. 2.Marine BiochemistryKagoshima UniversityKagoshimaJapan
  3. 3.Miyagi Cancer Center Research InstituteNatoriJapan
  4. 4.Cell Recognition Study, Institute of Molecular Biomembrane and GlycobiologyTohoku Pharmaceutical UniversitySendaiJapan

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