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Warthin’s Tumor

  • Joaquín J. García
Chapter

Abstract

Warthin’s tumor affects primarily adults and presents at a mean age of approximately 60 years. Women are involved less than men. The majority of cases involve the parotid gland, presenting as single or multiple masses. Warthin’s tumor may be well-circumscribed or multinodular, comprised of multiple cell types (columnar and cuboidal), and exhibit a variety of architectural patterns (solid, cystic, and papillary) (Figs. 28.1, 28.2, 28.3, 28.4, 28.5, 28.6, 28.7, 28.8, 28.9, 28.10, 28.11, 28.12, 28.13, 28.14, 28.15, 28.16, 28.17, 28.18 and 28.19).

Keywords

Adenolymphoma Cystadenolymphoma Papillary cystadenoma lymphomatosum 

Suggested Reading

  1. Ballo MS, Shin HJ, Sneige N. Sources of diagnostic error in the fine-needle aspiration diagnosis of Warthin's tumor and clues to a correct diagnosis. Diagn Cytopathol. 1997;17(3):230–4.CrossRefGoogle Scholar
  2. Di Palma S, Simpson RH, Skalova A, Michal M. Metaplastic (infarcted) Warthin’s tumor of the parotid gland: a possible consequence of fine needle aspiration biopsy. Histopathology. 1999;35:432–8.CrossRefGoogle Scholar
  3. Ellies M, Laskawi R, Arglebe C. Extraglandular Warthin’s tumors: clinical evaluation and long-term follow-up. Br J Oral Maxillofac Surg. 1998;36:52–3.CrossRefGoogle Scholar
  4. Ethunandan M, Pratt CA, Higgins B, Morrison A, Umar T, Macpherson DW, et al. Factors influencing the occurrence of multicentric and “recurrent” Warthin’s tumor: a cross sectional study. Int J Oral Maxillofac Surg. 2008;37:831–4.CrossRefGoogle Scholar
  5. Eveson JW, Cawson RA. Warthin’s tumor (cystadenolymphoma) of salivary glands. A clinicopathologic investigation of 278 cases. Oral Surg Oral Med Oral Pathol. 1986;61:256–62.CrossRefGoogle Scholar
  6. Flezar M, Pogacnik A. Warthin’s tumor: unusual vs. common morphological findings in fine needle aspiration biopsies. Cytopathology. 2002;13:232–41.CrossRefGoogle Scholar
  7. Gallo O, Bocciolini C. Warthin’s tumor associated with autoimmune diseases and tobacco use. Acta Otolaryngol. 1997;117:623–7.CrossRefGoogle Scholar
  8. Goonewardene SA, Nasuti JF. Value of mucin detection in distinguishing mucoepidermoid carcinoma from Warthin's tumor on fine needle aspiration. Acta Cytol. 2002;46(4):704–8.CrossRefGoogle Scholar
  9. Lam KH, Ho HC, Ho CM, Wei WI. Multifocal nature of adenolymphoma of the parotid. Br J Surg. 1994;81:1612–4.CrossRefGoogle Scholar
  10. Maiorano E, Lo Muzio L, Favia G, Piattelli A. Warthin’s tumor: a study of 78 cases with emphasis on bilaterality, multifocality and association with other malignancies. Oral Oncol. 2002;38:35–40.CrossRefGoogle Scholar
  11. Pinkston JA, Cole P. Cigarette smoking and Warthin's tumor. Am J Epidemiol. 1996;144(2):183–7.CrossRefGoogle Scholar
  12. Sadetzki S, Oberman B, Mandelzweig L, Chetrit A, Ben-Tai T, Jarus-Hakak A, et al. Smoking and risk of parotid gland tumors: a nationwide case-control study. Cancer. 2008;112:1974–82.CrossRefGoogle Scholar
  13. Seifert G, Bull HG, Donath K. Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch A Pathol Anat Histol. 1980;388:13–38.CrossRefGoogle Scholar
  14. Skalova A, Vanecek T, Simpson RH, Vazmitsel MA, Majewska H, Mukensnabi P, et al. CRTC1-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic ploeomrphic adenoma of salivary glands. Am J Surg Pathol. 2013;37:1743–50.CrossRefGoogle Scholar
  15. Veder LL, Kerrebijn JD, Smedts FM, den Bakker MA. Diagnostic accuracy of fine-needle aspiration cytology in Warthin tumors. Head Neck. 2010;32:1635–40.CrossRefGoogle Scholar
  16. Verma K, Kapila K. Salivary gland tumors with a prominent oncocytic component. Cytologic findings and differential diagnosis of oncocytomas and Warthin's tumor on fine needle aspirates. Acta Cytol. 2003;47(2):221–6.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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