Polymorphous adenocarcinoma affects children and adults and presents at a mean age of approximately 60 years. Women are involved more than men. The majority of cases involve minor salivary glands, presenting as single or multiple masses. Most cases of polymorphous adenocarcinoma behave as low- to intermediate-grade malignancies. Polymorphous adenocarcinoma may be well-circumscribed or infiltrative, comprised almost exclusively of one cell type (ductal), and exhibit a variety of architectural patterns (solid, trabecular, cribriform, microcystic, and papillary-cystic) (Figs. 24.1, 24.2, 24.3, 24.4, 24.5, 24.6, 24.7, 24.8, 24.9, 24.10, 24.11, 24.12, 24.13, 24.14, 24.15, 24.16, 24.17, 24.18, 24.19, 24.20, 24.21, 24.22, 24.22, 24.23, 24.24, 24.25, 24.26, 24.27 and 24.28).
This is a preview of subscription content, log in to check access.
Darling MR, Schneider JW, Phillips VM. Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers. Oral Oncol. 2002;38(7):641–5.CrossRefGoogle Scholar
Edwards PC, Bhuiya T, Kelsch RD. C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):586–93.CrossRefGoogle Scholar
Edwards PC, Bhuiya T, Kelsch RD. Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(5):613–9.CrossRefGoogle Scholar
Evans HL, Luna MA. Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol. 2000;24(10):1319–28.CrossRefGoogle Scholar
Martins C, Fonseca I, Roque L, Ribeiro C, Soares J. Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Cancer Genet Cytogenet. 2001;128(2):130–6.CrossRefGoogle Scholar
Saenz-Santamaria J, Catalina-Fernandez I. Polymorphous low-grade adenocarcinoma of the salivary gland. Diagnosis by fine needle aspiration cytology. Acta Cytol. 2004;48(1):52–6.CrossRefGoogle Scholar
Simpson RH, Pereira EM, Ribeiro AC, Abdulkadir A, Reis-Filho JS. Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology. 2002;41(3):250–9.CrossRefGoogle Scholar