Advertisement

Oncocytoma

  • Joaquín J. García
Chapter

Abstract

Oncocytoma is the benign counterpart of oncocytic carcinoma. Oncocytoma affects predominantly adults and presents at a mean age of approximately 65 years. Women and men are involved with similar frequency. The majority of cases involve the parotid gland, presenting as single or multiple masses. Oncocytoma may be well-circumscribed or multinodular, comprised almost exclusively of one cell type (oncocyte), and exhibit a variety of architectural patterns (nests, trabeculae, sheets, and duct-like configurations) (Figs. 20.1, 20.2, 20.3, 20.4, 20.5, 20.6, 20.7, 20.8, 20.9, 20.11, 20.12, 20.13, 20.14, 20.15, 20.16, 20.17, 20.18, 20.19, 20.20, 20.21, 20.22, 20.23, 20.24, 20.25 and 20.26).

Keywords

Oncocytic adenoma Oxyphilic adenoma 

Suggested Reading

  1. Barnes L, editor. Surgical pathology of the head and neck. 3rd ed. New York: CRC Press Inc; 2008.Google Scholar
  2. Blanck C, Eneroth CM, Jakobsson PA. Oncocytoma of the parotid gland: neoplasm or nodular hyperplasia? Cancer. 1970;25:919–25.CrossRefGoogle Scholar
  3. Capone RB, Ha PK, Westra WH, Pilkington TM, Sciubba JJ, Koch WM, et al. Oncocytic neoplasms of the parotid gland: a 16-year institutional review. Otolaryngol Head Neck Surg. 2002;126(6):657–62.CrossRefGoogle Scholar
  4. Deutsch E, Eilon A, Zelig S, Ariel I. Synchronous bilateral oncocytoma of the parotid glands. A case report. ORL J Otorhinolaryngol Relat Spec. 1984;46:66–8.CrossRefGoogle Scholar
  5. Garcia JJ, Hunt JL, Weinreb I, McHugh JB, Barnes EL, Cieply K, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinoma: utility as a diagnostic test. Hum Pathol. 2011;42:2001–9.CrossRefGoogle Scholar
  6. Ghandur-Mnaymneh L. Multinodular oncocytoma of the parotid gland: a benign; lesion simulating malignancy. Hum Pathol. 1984;15:485–6.CrossRefGoogle Scholar
  7. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR. p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol. 2007;1(2):123–31.CrossRefGoogle Scholar
  8. Ozolek JA, Bastacky SI, Myers EN, Hunt JL. Immunophenotypic comparison of salivary gland oncocytoma and metastatic renal cell carcinoma. Laryngoscope. 2005;115(6):1097–100.CrossRefGoogle Scholar
  9. Sorensen M, Baunsgaard P, Frederiksen P, Haahr PA. Multifocal adenomatous oncocytic hyperplasia of the parotid gland (unusual clear cell variant in two female siblings). Pathol Res Pract. 1986;181:254–9.CrossRefGoogle Scholar
  10. Thompson LD, Wenig BM, Ellis GL. Oncocytomas of the submandibular gland: a series of 22 cases and a review of the literature. Cancer. 1996;78:2281–7.CrossRefGoogle Scholar
  11. Verma K, Kapila K. Salivary gland tumors with a prominent oncocytic component. Cytologic findings and differential diagnosis of oncocytomas and Warthin's tumor on fine needle aspirates. Acta Cytol. 2003;47(2):221–6.CrossRefGoogle Scholar
  12. Weiler C, Reu S, Zengel P, Kirchner T, Ihrler S. Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma. Pathol Res Pract. 2009;205:838–42.CrossRefGoogle Scholar
  13. Zhou CX, Gao Y. Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. Oral Oncol. 2009;45(12):e232–8.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

Personalised recommendations