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Lymphoepithelial Carcinoma

  • Joaquín J. García
Chapter

Abstract

Lymphoepithelial carcinoma affects children and adults and presents at a mean age of approximately 55 years. Women and men are involved with similar frequency. The majority of cases involve the parotid gland, presenting as single or multiple masses. Most cases of lymphoepithelial carcinoma behave as intermediate- to high-grade malignancies. Lymphoepithelial carcinoma may be well-circumscribed or infiltrative, comprised of multiple cell types (epithelial and lymphoid), and exhibit a variety of architectural patterns (nests, cords, and sheets) (Figs. 16.1, 16.2, 16.3, 16.4, 16.5, 16.6, 16.7, 16.8, 16.9, 16.10, 16.11, 16.12, 16.13, 16.14, 16.15, 16.16 and 16.17).

Keywords

Undifferentiated carcinoma Undifferentiated carcinoma with lymphoid stroma Undifferentiated carcinoma of nasopharyngeal type Lymphoepithelial-like carcinoma Lymphoepithelioma-like carcinoma Carcinoma ex lymphoepithelial lesion Malignant lymphoepithelial lesion 

Suggested Reading

  1. Albeck H, Nielsen NH, Hansen HE, Bentzen J, Ockelmann HH, Bretlau P, et al. Epidemiology of nasopharyngeal and salivary gland carcinoma in Greenland. Arctic Med Res. 1992;51:189–95.PubMedGoogle Scholar
  2. Ambrosio MR, Masrogiulio MG, Barone A, Rocca BJ, Gallo C, Lazzi S, et al. Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature. Diagn Pathol. 2013;8:115.CrossRefGoogle Scholar
  3. Bialas M, Sinczak A, Choinska-Stefanska A, Zygulska A. EBV-positive lymphoepithelial carcinoma of salivary gland in a woman of a non-endemic area--a case report. Pol J Pathol. 2002;53(4):235–8.PubMedGoogle Scholar
  4. Friborg J, Hamilton-Therkildsen M, Homoe P, Kristensen C, Hui A, Liu FF, et al. A spectrum of basaloid morphology in a subset of EBV-associated “lymphoepithelial carcinomas” of major salivary glands. Head Neck Pathol. 2012;6:445–50.CrossRefGoogle Scholar
  5. Hamilton-Dutoit SJ, Therkildsen M, Neilsen NH, Jensen H, Hansen JP, Pallesen G. Undifferentiated carcinoma of the salivary gland in Greenlandic Eskimos: demonstration of Epstein-Barr virus DNA by in situ nucleic acid hybridization. Hum Pathol. 1991;22:811–5.CrossRefGoogle Scholar
  6. Hsiung CY, Huang CC, Wang CJ, Huang EY, Huang HY. Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns. Br J Radiol. 2006;79:52–5.CrossRefGoogle Scholar
  7. Jen KY, Cheng J, Li J, Wu L, Li Y, Yu S, et al. Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas. Int J Cancer. 2003;105(5):654–60.CrossRefGoogle Scholar
  8. Jen KY, Higuchi M, Cheng J, Li J, Wu LY, Li YF, et al. Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas. Virus Genes. 2005;30(2):223–35.CrossRefGoogle Scholar
  9. Kuo T, Hsueh C. Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating strong association with Epstein-Barr virus. Histopathology. 1997;31:75–82.CrossRefGoogle Scholar
  10. Leung SY, Chung LP, Yuen ST, Ho CM, Wong MP, Chan SY. Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. J Clin Pathol. 1995;48:1022–7.CrossRefGoogle Scholar
  11. Li F, Zhu G, Wang Y, Wang Y, Chent T, Ji Q. A clinical analysis of 37 cases with lymphoepithelial carcinoma of the major salivary gland treated by surgical resection and postoperative radiotherapy: a single institution study. Med Oncol. 2014;31:957.CrossRefGoogle Scholar
  12. Nagao T, Ishida Y, Sugano I, Tajima Y, Matsuzaki O, Hino T, et al. Epstein-Barr virus-associated undifferentiated carcinoma with lymphoid stroma of the salivary gland in Japanese patients: comparison with benign lymphoepithelial lesion. Cancer. 1996;78:695–703.CrossRefGoogle Scholar
  13. Saku T, Cheng J, Jen KY, Tokunaga M, Li J, Zhang W, et al. Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: a clinicopathologic study of 160 cases. Arkh Patol. 2003;65(2):35–9.PubMedGoogle Scholar
  14. Sheen TS, Tsai CC, Ko JY, Chang YL, Hsu MM. Undifferentiated carcinoma of the major salivary glands. Cancer. 1997;80:357–63.CrossRefGoogle Scholar
  15. Tsai CC, Chen CL, Hsu HC. Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. Hum Pathol. 1996;27:258–62.CrossRefGoogle Scholar
  16. Wang CP, Chang YL, Ko JY, Lou PJ, Yeh CF, Sheen TS. Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands. Cancer. 2004;101(9):2020–7.CrossRefGoogle Scholar
  17. Wenig BM. Lymphoepithlial-like carcinomas of the head and neck. Semin Diagn Pathol. 2015;32:74–86.CrossRefGoogle Scholar
  18. Wu DL, Shemen L, Brady T, Saw D. Malignant lymphoepithelial lesion of the parotid gland: a case report and review of the literature. Ear Nose Throat J. 2001;80(11):803–6.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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