Epithelial-Myoepithelial Carcinoma

  • Joaquín J. García


Epithelial-myoepithelial carcinoma affects children and adults and presents at a mean age of approximately 60 years. Women are involved slightly more than men. The majority of cases involve major salivary glands, presenting as single or multiple masses. Most cases of epithelial-myoepithelial carcinoma behave as low- to intermediate-grade malignancies; however, a subset of cases with high-grade transformation (necrosis, elevated mitotic activity, and cytomorphologic atypia) are predisposed to recurrence, lymph node involvement, and distant metastasis. Epithelial-myoepithelial carcinoma may be well-circumscribed or infiltrative, comprised of multiple cell types (ductal and myoepithelial), and exhibit a variety of architectural patterns (cystic and solid) (Figs. 13.1, 13.2, 13.3, 13.4, 13.5, 13.6, 13.7, 13.8, 13.9, 13.10, 13.11, 13.12, 13.13, 13.14, 13.15, 13.16, 13.17, 13.18, 13.19, 13.20, 13.21, 13.22, 13.23, 13.24, 13.25, 13.26, 13.27, 13.28, 13.29, 13.30, 13.31, 13.32, 13.33, 13.34, 13.35 and 13.36).


Adenomyoepithelioma Clear cell adenocarcinoma Glycogen-rich adenocarcinoma Clear cell carcinoma 

Suggested Reading

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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