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Clear Cell Carcinoma

  • Joaquín J. García
Chapter

Abstract

Clear cell carcinoma affects primarily adults and presents at a mean age of approximately 60 years. Women are involved more than men. The majority of cases involve minor salivary glands in the oral cavity, presenting as single or multiple masses. Most cases of clear cell carcinoma behave as low-grade malignancies. Clear cell carcinoma is infiltrative, comprised of one cell type (ductal), and may exhibit a variety of architectural patterns (single cells, nests, trabeculae, and solid) with or without hyalinized stroma (Figs. 12.1, 12.2, 12.3, 12.4, 12.5, 12.6, 12.7, 12.8, 12.9, 12.10, 12.11, 12.12, 12.13, 12.14, 12.15, 12.16, 12.17, 12.18, 12.19 and 12.20).

Keywords

Clear cell adenocarcinoma Hyalinizing clear cell carcinoma 

Suggested Reading

  1. Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50(7):559–70.CrossRefGoogle Scholar
  2. Jin R, Craddock KJ, Irish JC, Perez-Ordonez B, Weinreb I. Recurrent hyalinizing clear cell carcinoma of the base of tongue with high-grade transformation and EWSR1 gene rearrangement by FISH. Head Neck Pathol. 2012;6(3):389–94.CrossRefGoogle Scholar
  3. Lai G, Nemolato S, Lecca S, Parodo G, Medda C, Faa G. The role of immunohistochemistry in the diagnosis of hyalinizing clear cell carcinoma of the minor salivary gland: a case report. Eur J Histochem. 2008;52:251–4.CrossRefGoogle Scholar
  4. Milchgrub S, Gnepp DR, Vuitch F, Delgado R, Albores-Saavedra J. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol. 1994;18(1):74–82.CrossRefGoogle Scholar
  5. Milchgrub S, Vuitch F, Saboorian MH, Hameed A, Wu H, Albores-Saavedra J. Hyalinizing clear-cell carcinoma of salivary glands in fine-needle aspiration. Diagn Cytopathol. 2000;23(5):333–7.CrossRefGoogle Scholar
  6. O’Sullivan-Mejia ED, Massey HD, Faquin WC, Powers CN. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. 2009;3:179–85.CrossRefGoogle Scholar
  7. Shah AA, LeGallo RD, van Zante A, Frierson HF Jr, Mills SE, Berean KW, et al. EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol. 2013;37(4):571–8.CrossRefGoogle Scholar
  8. Simpson RH, Sarsfield PT, Clarke T, Babajews AV. Clear cell carcinoma of minor salivary glands. Histopathology. 1990;17(5):433–8.CrossRefGoogle Scholar
  9. Solar AA, Schmidt BL, Jordan RC. Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature. Cancer. 2009;115(1):75–83.CrossRefGoogle Scholar
  10. Tanguay J, Weinreb I. What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma. Head Neck Pathol. 2013;7:28–34.CrossRefGoogle Scholar
  11. Wang B, Brandwein M, Gordon R, Robinson R, Urken M, Zarbo RJ. Primary salivary clear cell tumors—a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Arch Pathol Lab Med. 2002;126(6):676–85.PubMedGoogle Scholar
  12. Weinreb I. Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol. 2013;7(Suppl 1):S20–9.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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