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Free radicals and antioxidants in human diseases

  • J. Pincemail
Chapter

Summary

Increased free radicals formation derived from abnormal metabolism of oxygen has been implicated in over 100 different human diseases which may be classified into six categories: chemical and xenobiotic toxicity, radiation injury, hyperoxygenation syndromes, inflammatory conditions, postischemic reperfusion injury and degenerative conditions. As their in vivo evidence always remains a difficult challenge, there is, however, a great deal of confusion about their precise role in the development of human diseases. Whatever the precise mechanism, preventing free radical generation by appropriate antioxidant therapy should provide beneficial clinical consequences.

Keywords

Human Immunodeficiency Virus Free Radical Electron Spin Resonance Signal Free Radical Production Adult Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gutteridge, J.M.C. (1994a) Biological origin of free radicals, and mechanisms of antioxidant protection. Chemico-Biological Interactions 91: 113–140.Google Scholar
  2. 2.
    Gerschman, R., Gilbert, D.L., Nye, S.W., Dwyer, P. and Fenn, W.O. (1954) Oxygen poisoning and x-irradiation: a mechanism in common. Science 119: 623–626.PubMedGoogle Scholar
  3. 3.
    Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry. J. Geront 11: 298–300.PubMedGoogle Scholar
  4. 4.
    Laborit, H., Baron, C., Berthou, J., Drouet, J., Gerard, J., Jouany, J.M., Narvaes, C., Niaussat, P and Weber, B. (1960) Introduction à l’étude des antioxydants et des structures à electrons célibataires en biologie. 2ème partie: étude expérimentale et réanimation métabolique. Agressologie 1: 133–155.Google Scholar
  5. 5.
    Paeck, R., Rubin, P. and Bauerle, P.A. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV. EMBO J. 10: 2247–2258.Google Scholar
  6. 6.
    McCord, J.M., Keele, B.B., Jr. and Fridovich, J.J. (1969) Superoxide dismutase, an enzyme function for erythrocuprein. J. Biol. Chem. 244: 6049–6055.PubMedGoogle Scholar
  7. 7.
    Klebanoff, S.J. (1982) The iron-H202-iodide cytotoxic system. J. Exp. Med. 156: 1262–1267.PubMedGoogle Scholar
  8. 8.
    Bast, A. (1986) Is formation of reactive oxygen species by cytochrome P-450 perilous and predictable? Biochem. Pharmacol. 37: 569–571.Google Scholar
  9. 9.
    Shapiro, B.M. (1991) The control of oxidant stress at fertilization. Science 252: 533–536.PubMedGoogle Scholar
  10. 10.
    Sies, H. (1991) In: H. Sies (ed.): Oxidative Stress. Oxidants and Antioxidants. Academic Press, London, pp 15–22.Google Scholar
  11. 11.
    Gutteridge, J.M.C. (1993) Invited review free radicals in disease processes: a complication of cause and consequence. Free Rad. Res. Comm. 19: 141–158.Google Scholar
  12. 12.
    Janero, D.R. (1990) Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Rad. Biol. Med. 9: 515–540.PubMedGoogle Scholar
  13. 13.
    Springfield, J.R. and Levitt, M.D. (1994) Pitfalls in the use of breath pentane measurements to assess lipid peroxidation. J. Lip. Res. 35: 1497–1504.Google Scholar
  14. 14.
    Stocker, R. and Frei, B. (1991) Endogenous antioxidant defences in human blood plasma. In: H. Sies (ed.): Oxidative Stress. Oxidants and Antioxidants. Academic Press, London, pp 213–243.Google Scholar
  15. 15.
    Burton, G.W. and Ingold, K.U. (1989) Vitamin E as an in vitro and in vivo antioxidant. In: A.T. Diplock, L.J. Machlin, L. Packer and W.A. Pryor (eds): Vitamin E Biochemistry and Health Implications. Vol. 570, Ann. New York Acad. Sci., pp 7–22.Google Scholar
  16. 16.
    Grootveld, M. and Halliwell, B. (1987) Measurement of allantoin and uric acid in human body fluids. A potential index of free radical reactions in vivo? Biochem. J. 243: 803–808.PubMedGoogle Scholar
  17. 17.
    Grootveld, M. and Halliwell, B. (1986) Aromatic hydroxylation as potential measure of hydroxyl radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids. Biochem. J. 237: 499–504.PubMedGoogle Scholar
  18. 18.
    Cantilena, L.R., Smith, R.P., Frasur, S., Kruszyna, H., Kruszyna, R. and Wilcox, D.E. (1992) Nitric oxide hemoglobin in patients receiving nitroglycerin as detected by electron paramagnetic resonance spectroscopy. J. Lab. Clin. Med. 120: 902–907.PubMedGoogle Scholar
  19. 19.
    Pryor, W.A. and Godber, S.S. (1991) Noninvasive measures of oxidative stress status in humans. Free Rad. Biol. Med. 10: 177–184.PubMedGoogle Scholar
  20. 20.
    Halliwell, B. (1987) Oxygen radicals and metals ions: potential antioxidant intervention strategies In: C.E. Cross (ed.): Oxygen Radicals and Human Disease. Ann. Intern. Med. 107: 526–545.Google Scholar
  21. 21.
    Lunec, J. (1991) Free radicals and the immune response. Molec. Aspects Med. 12: 85–174.Google Scholar
  22. 22.
    Powell, S.R. and Tortolani, A.J. (1992) Recent advances in the role of reactive oxygen intermediates in ischemic injury. J. Surg. Res. 53: 417–429.PubMedGoogle Scholar
  23. 23.
    Hecht, S.M. (1986) DNA strand scission by activated bleomycin group antibiotics. Fed. Proc. 45: 2784–2791.PubMedGoogle Scholar
  24. 24.
    Young, I.S., Trouton, T.G., Torney, J.J., McMaster, D., Callender, M.E. and Trimble, E.R. (1994) Antioxidant status and lipid peroxidation in hereditary haemochromatosis. Free Rad. Biol. Med. 16: 393–397.PubMedGoogle Scholar
  25. 25.
    Chiu, D. and Lubin, B. (1980) Abnormal vitamin E and glutathione peroxidase levels in sickle cell anemia: evidence for increased susceptibility to lipid peroxidation in vivo. J. Lab. Clin. Med. 94: 542–548.Google Scholar
  26. 26.
    Peters, T.J., O’Connell, M.J., Venkatesan, S. and Ward, R.J. (1986) Evidence for free radical-mediated damage in experimental and human alcoholic disease. In: C. Rice-Evans (ed.): Free Radicals, Cell Damage and Disease. Richelieu Press, London, pp 99–110.Google Scholar
  27. 27.
    Korkina, L.G., Afanas’ef, I.B. and Diplock, A.T. (1993) Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident. Biochem. Soc. Trans. 21(3): 314S.PubMedGoogle Scholar
  28. 28.
    Mecocci, P., MacGarvey, U., Kaufman, A. Koontz, D., Shoffner, J.M., Wallace, D.C. and Beal, M.F. (1993) Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34: 609–616.PubMedGoogle Scholar
  29. 29.
    Frey, K.F., Brubacher, G.B. and Stähelin, H.B. (1987) Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am. J. Clin. Nutr. 45: 1368–1377.Google Scholar
  30. 30.
    Harman, D. (1984) Free radical theory of aging: the “free-radical diseases”. Age 7: 111–131.Google Scholar
  31. 31.
    Clark, I.A. and Hunt, N.H. (1983) Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infect. Immun. 39: 1–6.PubMedGoogle Scholar
  32. 32.
    Janero, D.R. (1991) Therapeutic potential of vitamin E in the pathogensis of spontaneous atherosclerosis. Free Rad. Biol. Med. 11: 129–144.PubMedGoogle Scholar
  33. 33.
    Illingworth, D.R. (1993) The potential role of antioxidants in the prevention of atherosclerosis. J. Nut. Sc. Vitam. 39: S43–S47.Google Scholar
  34. 34.
    Pincemail, J., Bertrand, Y., Hanique, G., Denis, B., Leenaerts, L., Vankeerberghen, L. and Deby, C. (1989a) Evolution of vitamin E deficiency in patients with adult respiratory distress syndrome. Ann. NY Acad. Sci. 570: 498–499.Google Scholar
  35. 35.
    Malvy, J.-M., D., Lebranchu, Y., Richard, M.-J., Arnaud, J. and Favier, A. (1993) Oxidative metabolism and severe asthma in children. Clin. Chim. Acta. 218: 117–120.PubMedGoogle Scholar
  36. 36.
    Leuenberger, P. (1994) Respiratory diseases and oxidants. Schweiz. Medizin. Wochen- schrift. 124: 129–135.Google Scholar
  37. 37.
    Coghlan, J.G., Flitter, W.D., Holle, A.E., Norell, ML, Mitchell, A.G., Ilsley, C.D. and Slater, T.F. (1991a) Detection of free radicals and cholesterol hydroperoxides in blood taken from the coronary sinus of man during percutaneous transluminal coronary angioplasty. Free Rad. Res. Comm. 14: 409–417.Google Scholar
  38. 38.
    Johnson, K.J., Rehan, A. and Ward, P.A. (1987) Upjohn Symposium. The role of oxygen radicals in kidney disease. Kidney Disease, pp 115–121.Google Scholar
  39. 39.
    Pincemail, J., Defraigne, J.O., Franssen, C., Bonnet, P., Deby-Dupont, G., Pirenne, J., Deby, C., Lamy, M., Limet, M. and Meurise, M. (1993) Evidence for free radical formation during human kidney transplantation. Free Rad. Biol. Med. 15: 343–348.PubMedGoogle Scholar
  40. 40.
    Scott, P., Bruce, C., Schofield, D., Shiel, N., Braganza, J.M. and McCloy, R.F. (1993) Vitamin C status in patients with acute pancreatitis. Br. J. Surg. 80: 750–754.PubMedGoogle Scholar
  41. 41.
    Humad, S., Zarling, E., Clapper, M. and Skosey, J.L. (1988) Breath pentane excretion as a marker of disease activity in rheumatoid arthritis. Free Rad. Res. Comm. 5: 101–106.Google Scholar
  42. 42.
    Meier, B., Radeke, H.H., Selle, S., Raspe, H.H., Sies, H., Resch, K. and Habermehl, G. (1990) Human fibroblasts release reactive oxygen species in response to treatment with synovial fluids from patients suffering from arthritis. Free Rad. Res. Comm. 8: 149–160.Google Scholar
  43. 43.
    Hall, E.D. and Braughler, J.M. (1989) Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Rad. Biol. Med. 6: 303–313.PubMedGoogle Scholar
  44. 44.
    Adams, J.D. and Odunze, I.N. (1991) Oxygen free radicals and Parkinson’s disease. Free Rad. Biol. Med. 10: 161–169.PubMedGoogle Scholar
  45. 45.
    Girotti, M.J., Khan, N. and McLellan, B.A. (1991) Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients. J. of Trauma 31: 32–35.Google Scholar
  46. 46.
    Spector, A. (1991) The lens and oxidative stress. In: H. Sies (ed.): Oxidative Stress. Oxidants and Antioxidants. Academic Press, London, pp 529–558.Google Scholar
  47. 47.
    Fuchs, J. and Packer, L. (1991) Photooxidative stress in the skin. In: H. Sies (ed): Oxidative Stress, Oxidants and Antioxidants. Academic Press, London, pp 559–583.Google Scholar
  48. 48.
    Sinclair, A.J., Barnett, A.H. and Lunec, J. (1990) Free radicals and antioxidant systems in health and disease. Brit. J. Hosp. Med. 43: 334–344.Google Scholar
  49. 49.
    Bulkley, G.B. (1993) Free radicals and other reactive oxygen metabolites: clinical relevance and the therapeutic efficacy of antioxidant therapy. Surgery 113: 479–483.PubMedGoogle Scholar
  50. 50.
    Garlick, P.B., Davies, M.J., Hearse, D.J. and Slater, T.F. (1987) Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy. Cir. Res. 61: 757–760.Google Scholar
  51. 51.
    Pietri, S., Culcasi, M. and Cozzone, P.J. (1989) Real-time continuous-flow spin trapping of hydroxyl radical in the ischemic and post-ischemic myocardium. Eur. J. Biochem. 186: 163–173.PubMedGoogle Scholar
  52. 52.
    Nilsson, U.A., Lundgren, O., Haglind, E, and Bylund-Fellenius, A.C. (1989) Radical production during in vivo intestinal reperfusion in the cat. Am. J Physiol. 257: G409– G414.PubMedGoogle Scholar
  53. 53.
    Pincemail, J., Defraigne, J.O., Franssen, C., Defechereux. T., Canivet, J.-J., Philippart, C. and Meurisse, M. (1990) Evidence of in vivo free radical generation by spin trapping with alpha-phenyl N-tert-butyl nitrone during ischemia-reperfusion in rabbit kidneys. Free Rad. Res. Comm. 9: 3–6.Google Scholar
  54. 54.
    Tosaki, A., Bagchi, D., Pali, T., Cordis, G.A. and Das, D.P. (1993) Comparion of esr and HPLC methods for the detection of OH radicals in ischemic-reperfused hearts. Biochem. Pharmacol. 45: 961–969.PubMedGoogle Scholar
  55. 55.
    Li, X.Y., McCay, P.B., Zughaib, ML, Jeroudi, M.O., Triana, J.F. and Bolli, R. (1993) Demonstration of free radical generation in the “stunned” myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs. J. Clin. Invest. 92: 1025–1041.PubMedGoogle Scholar
  56. 56a.
    Connor, H.D., Gao, W., Mason, R.P. and Thurman, R.G. (1993) New reactive oxidizing species causes formation of carbon-centered radical adducts in organic extracts of blood following liver transplantation. Free Rad. Biol. Med. 16: 871–875.Google Scholar
  57. 56b.
    Omar, B., McCord, J. and Downey, J. (1991) Ischemia-reperfusion. In: H. Sies (ed.): Oxidative Stress. Oxidants and Antioxidants. Academic Press, London, pp 494–527.Google Scholar
  58. 57.
    Coghlan, J.G., Flitter, W.D., Isley, CD., Rees, A. and Slater, T.F. (1991b) Reperfusion of infarcted tissue and free radicals. Lancet 338: 1145PubMedGoogle Scholar
  59. 58.
    Faymonville, M.E., Pincemail, J., Duchateau, M.D., Paulus, J.M., Adam, A., Deby-Du- pont, G., Deby, C., Albert, A., Larbuisson, R., Limet, R. and Lamy, M. (1991) Myeloperoxidase and elastase as markers of leukocyte activation during cardiopulmonary bypass in humans. J. Thorac. Cardiovasc. Surg. 102: 309–317.PubMedGoogle Scholar
  60. 59.
    Cavarocchi, N.C., England, M.D., O’Brien, J.F., Solis, E., Russo, P., Schaff, H.V., Orszulak, T.A., Pluth, J.R. and Kaye, M.P. (1986) Superoxide generation during cardiopulmonary bypass: is there a role for vitamin E. J. Surg. Res. 40: 519–527.PubMedGoogle Scholar
  61. 60.
    Pincemail, J., Faymonville, M., Deby-Dupont, G., Thirion, A., Deby, C. and Lamy, M. (1989b) Neutrophils activation evidenced by plasmatic myeloperoxidase release during cardiopulmonary bypass. Consequence on vitamin E status. Ann. NY Acad. Sci. 570: 501–502.Google Scholar
  62. 61.
    Murphy, M.E., Kolvenback, R., Aleksis, M., Hansen, R. and Sies, H. (1992) Antioxidant depletion in aortic crossclamping ischemia: increase of the plasma alpha tocopheryl quinone/alpha-tocopherol ratio. Free Rad. Biol. Med. 13: 95–100.PubMedGoogle Scholar
  63. 62.
    Pepper, J.R., Mumby, S. and Gutteridge, J.M.C. (1994) Transient iron-overload with bleomycin-detectable iron present during cardiopulmonary bypass surgery. Free Rad. Res. Comm. 21: 53–58.Google Scholar
  64. 63.
    Ward, A., McBurney, A. and Lunec, J. (1994) Evidence for the involvement of oxygen- derived free radicals in ischemia-reperfusion injury. Free Rad. Res. Comm. 20: 21–28.Google Scholar
  65. 64.
    Culcasi, M., Pietri, S., Carrière, I., d’Arbigny, P. and Drieu, K. (1993) Electron-spin-resonance study of the protective effects of Ginkgo biloba (EGb 761) on reperfusion-in- duced free-radical generation associated with plasma ascorbate consumption during open-heart surgery in man. In: C. Ferradini, M.T. Droy-Lefaix and Y. Christen (eds): Advances in Gingko biloba Extract Research, Vol 2. Ginkgo Biloba (EGb 761) as Free Radical Scavenger pp 153–162.Google Scholar
  66. 65.
    Hartstein, G., Pincemail, J., Deby-Dupont, G., Deby, C., Larbuisson, R. and Lamy, M. (1993) Evidence for free radical formation during cardiopulmonary bypass in man. Anesthesio. 79: no. 3A A140.Google Scholar
  67. 66.
    Heim, K.F., Makila, U.-M., Leveson, R., Ledley, G.S., Thomas, G., Rackley, C. and Ramwell, P.W. (1987) Detection of pentane as a measurement of lipid peroxidation in humans using gas chromatography with a photoionization detector. In: M. Paubert- Braqut (ed.): Lipid Mediators in the Immunology of Shock. Nato ASI Series vol., 139. Plenum Press, New York, pp 103–108.Google Scholar
  68. 67.
    Serino, F., Citterio, F., Lippa, S., Oradei, A., Agnes, S., Nanni, A., Pozzetto, A., Littaru, G. and Castagneto, M. (1990) Coenzyme Q, alpha tocopherol and delayed function in human kidney transplantation. Transpl. Proc. 22: 2224–2225.Google Scholar
  69. 68.
    Rabl, H., Khoschorur, G., Colombo, T., Tatzber, F. and Esterbauer. H. (1992) Human plasma lipid peroxide levels show a strong transient increase after successful revascularization operations. Free Rad. Biol. Med. 13: 281–288.PubMedGoogle Scholar
  70. 69.
    Zimmerman, J.J. (1992) Oxyradical pathogenesis in sepsis, In: M. Lamy and L.G. Thijs (eds): Update in Intensive Care and Emergency Medicine. Mediators of Sepsis. Vol. 16, pp 136–151.Google Scholar
  71. 70.
    Pincemail, J., Deby-Dupont, G., Deby, C., Thirion, A., Torpier, G., Faymonville. M., Damas, P., Tomassini, M., Lamy, M. and Franchimont, P. (1991) Fast double antibody radioimmunoassay of human granulocytes myeloperoxidase and its application to plasma. J. Immunol. Meth. 137: 181–191.Google Scholar
  72. 71.
    Cochrane, C.G., Spragg, R., Revak, S.D., Cohen, A.B. and McGuire, W.W. (1983) The presence of neutrophil elastase and evidence of oxidant activity in bronchoalveolar lavage fluid. Am. Rev. Resp. Dis. 127: S25–S27.PubMedGoogle Scholar
  73. 72.
    Takeda, K., Shimada, Y., Amano, M., Sakai, T., Okada, T. and Yoshiya, I. (1984) Plasma lipid peroxides and alpha-tocopherol in critically ill patients. Crit. Car. Med. 12: 957–959.Google Scholar
  74. 73.
    Bertrand, Y., Pincemail, J., Hannique, G., Denis, B., Leenaerts, L., Vankeerberghen, L. and Deby, C. (1986) Differences in tocopherol-lipid ratio in ARDS and no ARDS patients. Int. Car. Med. 15: 557–559.Google Scholar
  75. 74.
    Keen, R.R., Stella, L., Flanigan, P. and Lands, W.E.M. (1991) Differential detection of plasma hydroperoxides in sepsis. Crit. Care Med. 19: 1114–1119.PubMedGoogle Scholar
  76. 75.
    Ogilvie, A.C., Groeneveld, A.B.J., Straub, J.P. and Thijs, L.G. (1991) Plasma lipid peroxides and antioxidants in human septic shock. Int. Care Med. 17: 40–44.Google Scholar
  77. 76.
    Toonen, T.R., Lewandoski, J.R. and Zimmerman, J.J. (1991) Longitudinal analysis of plasma tocopherol levels in patients with septic shock. Clin. Res. 39: 688.Google Scholar
  78. 77.
    Krsek-Staples, J.A., Kew, R.R. and Wester, R.O. (1992) Ceruloplasmin and transferrin levels are altered in serum and bronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 145: 1009–1015.PubMedGoogle Scholar
  79. 78.
    Quinlain, G.J., Evans, T.W. and Gutteridge, J.M.C. (1994a) Oxidative damage to plasma proteins in adult respiratory distress syndrome. Free Rad. Res. Comm.. 20: 289–298.Google Scholar
  80. 79.
    Quinlain, J.G., Evans, T.W. and Gutteridge, J.M.C. (1994b) Linoleic acid and protein thiol changes suggestive of oxidative damage in the plasma of patients with adult respiratory distress syndrome. Free Rad. Res. Comm. 20: 299–306.Google Scholar
  81. 80.
    Leff, J.A., Parsons, P.F., Day, C.E., Taniguchi, N., Jochum, M., Fritz, H., Moore, F.A., Moore, E., McCord, J.M. and Repine, J.E. (1993) Serum antioxidants as predictors of adult respiratory distress syndrome in patients with sepsis. Lancet 341: 777–780.PubMedGoogle Scholar
  82. 81.
    Baldwin, S.R., Simon, R.H., Grum, C.M., Ketai, L.H., Boder, L.A. and Devall, L.J. (1986) Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1: 11–14.PubMedGoogle Scholar
  83. 82.
    Pincemail, J., Deby, C., Dethier, A., Bertrand, Y., Lismonde, M. and Lamy, M. (1986) Pentane measurement in man as an index of lipid peroxidation. Bioelectro. and Bioenerg. 18: 117–126.Google Scholar
  84. 83.
    Nurcombe, H.L., Bucknall, R.C. and Edwards, S.W. (1991) Neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis: priming and activation in vivo. Ann. Rheum. Dis. 50: 196–200.Google Scholar
  85. 84.
    Gutteridge, J.M.C. (1987) Bleomycin-detectable iron in the knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin. Lancet 2: 415–421.Google Scholar
  86. 85.
    Merry, P., Grootveld, M., Lunec, J. and Blake, D.R. (1991) Oxidative damage to lipids within inflamed human joints provides evidence of radical-mediated hypoxic-reperfusion injury. Am. J. Clin. Nutr. 56: 362S–369S.Google Scholar
  87. 86.
    The place of oxygen free radicals in HIV infections (1994), presented at a meeting organized in France by A.E. Favier, published in Chemico-Biological Interactions (Guest Editor A.E. Favier), Vol. 91, pp 77–232.Google Scholar
  88. 87.
    Postaire, E., Massias, L., Lopez, O., Mollerau, M. and Hazebroucq, G. (1994) Alcanes measurements in human immunodeficiency virus infection. In: C. Pasquier, R.Y. Olivier, C. Auclair and L. Packer (eds): Oxidative Stress, Cell Activation and Viral Infection. Birkhäuser Verlag, Basel, pp 333–340.Google Scholar
  89. 88.
    Müller, F. (1992) Reactive oxygen intermediates and human immunodeficiency virus (HIV) infection. Free Rad. Biol. Med. 13: 651–657.PubMedGoogle Scholar
  90. 89.
    Staal, F.J.T., Roederer, M., Israelski, D.M., Buop, J., Mole, L.A., McShane, D., Deresinski, S.C., Ross, W., Sussman, H., Rago, P.A., Anderson, M.T., Moore, W., Elsa, W. and Hersenberg, L.A. (1992) Intracellular glutathione levels in T cells subset decrease in HIV infected patients. AIDS Res. Human Retroviruses 2: 311.Google Scholar
  91. 90.
    Dröge, W., Eck, H.-P., Mihm, S. and Galter, D. (1994) Abnormal redox regulation in HIV infection and other immunodeficiency diseases. In: C. Pasquier, R.Y. Olivier, C. Auclair and L. Packer (eds): Oxidative Stress, Cell Activation and Viral Infection. Birkhäuser Verlag, Basel, pp 285–299.Google Scholar
  92. 91.
    Favier, A., Sappey, C, Leclerc, P., Faure, P. and Micoud, M. (1994) Antioxidant status and lipid peroxidation in patients infected with HIV. Chemico-Biological Interactions 91: 165–180.PubMedGoogle Scholar
  93. 92.
    Sergeant, C., Simonoff, M., Hamon, C, Peuchant, E., Dumon, M.F., Clerc, M., Thomas, M.J., Constans, J., Conri, C, Pelligrin, J.L. and Leng, B. (1994) Plasma antioxidant status (selenium, retinol and α-tocopherol) in HIV infection. In: C. Pasquier, R.Y. Olivier, C. Auclair and L. Packer (eds): Oxidative Stress, Cell Activation and Viral Infection, Birkhäuser Verlag, Basel, pp 341–351.Google Scholar
  94. 93.
    Legrand-Poels, S., Vaira, D., Pincemail, J., Van de Vorst, A. and Piette, J. (1990) Activation of human immunodeficiency virus type 1 by oxidative stress. AIDS Res. 6: 1389–1397.Google Scholar
  95. 94.
    Uden, S., Bilton, D., Nathan, L., Hunt, L.P., Main, C., Braganza, J.M. (1990) Antioxidant therapy for reccurent pancreatitis: placebo-controlled trial. Alim. Pharmacol. Therapeu. 4: 357–371.Google Scholar
  96. 95.
    Clemens, M.R. (1990) Antioxidant therapy in hematological disorders. Ad. Exp. Med. Biol. 264: 423–433.Google Scholar
  97. 96.
    Anonymous (1990) Antioxidants in therapy and preventive medicine. Ad. Exp. Med. Biol. 264: 1–576.Google Scholar
  98. 97.
    Müller, D.P. (1990) Antioxidant therapy in neurological disorders. Adv. Exp. Med. Biol. 264: 475–484.PubMedGoogle Scholar
  99. 98.
    Hearse, D.J. (1991) Prospects for antioxidant therapy in cardiovascular medicine. Am. J. Med. 91: 118S–121S.PubMedGoogle Scholar
  100. 99.
    Youn, Y.-K., LaLonde, C. and Demling, R. (1991) Use of antioxidant therapy in shock and trauma. Circ. Shock 35: 245–249.PubMedGoogle Scholar
  101. 100.
    Chow, C.K. (1991) Vitamin E and oxidative stress. Free Rad. Biol. Med. 11: 215–232.PubMedGoogle Scholar
  102. 101.
    Deucher, G.P. (1992) Antioxidant therapy in the aging process. In: I. Emerit and B. Chance (eds): Free Radicals and Aging, Birkhäuser Verlag, Basel, pp 428–437.Google Scholar
  103. 102.
    Manson, J.E., Gaziono, J.M., Jonas, M.A. and Hennkens, C.H. (1993) Antioxidants and cardiovascular disease. J. Am. Coll. Nut. 12: 426–432.Google Scholar
  104. 103.
    Goode, H.F. and Webster, N.R. (1993) Free radicals and antioxidants in sepsis. Crit. Care Med. 21: 1770–1776.PubMedGoogle Scholar
  105. 104.
    Packer, L. (1993) The role of anti-oxidative treatment in diabetes mellitus. Diabetol 36: 1212–1213.Google Scholar
  106. 105.
    Levander, O.A. and Ager, A.L. (1993) Malarial parasites and antioxidant nutrients. Parasitology 107: S95–S106.PubMedGoogle Scholar
  107. 106.
    Sies, H. (1993) Efficacy of vitamin E in the Human. Veris, Lagrange, Illinois, USA.Google Scholar
  108. 107.
    Schiller, H.J., Reilly, P.M. and Bulkley, G.B. (1993) Antioxidant therapy. Crit. Care. Med. 21: S92–S102.PubMedGoogle Scholar
  109. 108.
    Yoshikawa, T., Naito, Y. and Kondon, M. (1993) Antioxidant therapy in digestive diseases. J. Nutr. Sc. Vitam. 39: S35–S41.Google Scholar
  110. 109.
    Rice-Evans, C.A. and Diplock, A.T. (1993) Current status of antioxidant therapy. Free Rad. Biol. Med. 15: 77–96.PubMedGoogle Scholar
  111. 110.
    Baruchel, S., Bounous, G. and Gold, P. (1994) Place for an antioxidant therapy in human immunodeficiency virus (HIV) infection. In: C. Pasquier, R.Y. Olivier, C. Auclair and L. Packer (eds): Oxidative Stress, Cell Activation and Viral Infection. Birkhäuser Verlag, Basel, pp 311–321.Google Scholar
  112. 111.
    Parthasarathy, S. and Rankin, S.M. (1992) Role of oxidised low density lipoproteins in atherogenesis. Prog. Lipid Res. 31: 127–143.PubMedGoogle Scholar
  113. 112.
    Dröge, W. (1993) Cysteine and gluthathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine. Pharmacology 46: 61–65.PubMedGoogle Scholar
  114. 113.
    Schneeberger, H., Schleibner, S., Schilling, M., Illner, W.D., Abendroth, D., Hancke, E., Janicke, U. and Land, W. (1990) Prevention of acute renal failure after kidney transplantation with rh-SOD; interim analysis of a double-bind placebo-controlled trial. Transp. Proceed. 22: 2224–2225.Google Scholar
  115. 114.
    Ganguly, P.K. (1991) Antioxidant therapy in congestive heart failure: is there any advantage? J. Inter. Med. 229: 205–208.Google Scholar
  116. 115.
    Hennekens, C.H., Buring, J.E. and Peto, R. (1994) Antioxidant vitamins-benefits not yet proved. New Engl. J. Med. 330: 1080–1081.PubMedGoogle Scholar
  117. 116.
    Flohé, L. (1988) Superoxide dismutase for therapeutic use: clinical experience, dead ends and hopes. Mol. Cell. Biochem. 84: 123–131.PubMedGoogle Scholar
  118. 117.
    Przyklenk, K. and Kloner, R.A. (1989) “Reperfusion injury” by oxygen-derived free radicals? Cir. Res. 64: 86–96.Google Scholar
  119. 118.
    Herbert, V. (1993) Dangers of iron and vitamin C supplements. J. Am. Diet. Assoc. 93: 526–527.Google Scholar
  120. 119.
    Turner, J.J.O., Rice-Evans, C., Davies, M.J. and Newma, E.S.R. (1991) The formation of free radicals by cardiac monocytes under oxidative stress and the effects of electron- donating drugs. Biochem. J. 211: 833–837.Google Scholar
  121. 120.
    Gutteridge, J.M.C., Quinlan, G.J., Swain, J. and Cox, J. (1994b) Ferrous ion formation by ferrioxamine prepared from aged desferrioxamine: a potential prooxidant property. Free Rad. Biol. Med. 16: 733–739.PubMedGoogle Scholar
  122. 121.
    Barinaga, M. (1991) Vitamin C gets a little respect. Science 254: 374–376.PubMedGoogle Scholar
  123. 122.
    Herbert, V. (1994) The antioxidant supplement myth. Am. J. Clin. Nutr. 60: 157–158.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 1995

Authors and Affiliations

  • J. Pincemail
    • 1
  1. 1.Department of Cardiovascular SurgeryUniversity of Liège, CHU B35LiègeBelgium

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