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Chemokine receptors

  • Ingrid U. Schraufstätter
  • Hiroshi Takamori
  • Robert C. Hoch
Chapter
Part of the Progress in Inflammation Research book series (PIR)

Abstract

The chemokines exert their influence on target cells via specific G-protein-coupled receptors with seven membrane spanning domains, as predicted by hydropathy plotting. With an estimated 40 to 50 different chemokines, with several of the receptors binding multiple ligands, and with variations in target cell specificity between different species, the individual roles of these receptors are far from clear. More than a dozen putative chemokine receptors have been cloned including several orphan receptors that share sequence homology with the chemokine receptors (reviewed in [1]), but whose ligands are not yet known. These receptors share certain motives such as a DRYLAIV sequence in the second intracellular loop which appears to be involved in G-protein coupling.

Keywords

Chemokine Receptor Extracellular Loop RBL2H3 Cell Formyl Peptide Receptor CXCR2 Mutant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 1998

Authors and Affiliations

  • Ingrid U. Schraufstätter
    • 1
  • Hiroshi Takamori
    • 2
  • Robert C. Hoch
    • 1
  1. 1.Dept. of ImmunologyThe Scripps Research InstituteLa JollaUSA
  2. 2.Dept. of SurgeryKumamoto UniversityKumamotoJapan

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