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Virus population dynamics, fitness variations and the control of viral disease: an update

  • Esteban Domingo
  • Antonio Mas
  • Eloisa Yuste
  • Nonia Pariente
  • Saleta Sierra
  • Mónica Gutiérrez-Rivas
  • Luis Menéndez-Arias
Chapter
Part of the Progress in Drug Research book series (PDR, volume 57)

Summary

Viral quasispecies dynamics and variations of viral fitness are reviewed in connection with viral disease control. Emphasis is put on resistance of human immunodeficiency virus and some human DNA viruses to antiviral inhibitors.

Future trends in multiple target antiviral therapy and new approaches based on virus entry into error catastrophe (extinction mutagenesis) are discussed.

Keywords

Virus quasispecies HIV fitness influenza herpes hepatitis B inhibitor resistance extinction mutagenesis 

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Copyright information

© Springer Basel AG 2001

Authors and Affiliations

  • Esteban Domingo
    • 1
  • Antonio Mas
    • 1
  • Eloisa Yuste
    • 1
  • Nonia Pariente
    • 1
  • Saleta Sierra
    • 2
  • Mónica Gutiérrez-Rivas
    • 1
  • Luis Menéndez-Arias
    • 1
  1. 1.Centro de Biología Molecular “Severo Ochoa” Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid CantoblancoMadridSpain
  2. 2.Institut für VirologieUniversität zu KölnKölnGermany

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