Viral, Fungal and Atypical Bacterial Infections in Cystic Fibrosis

  • Barbara Przyklenk
  • Adolf Bauernfeind
Part of the Respiratory Pharmacology and Pharmacotherapy book series (RPP)


The role of respiratory viral and fungal agents in cystic fibrosis (CF) was investigated. Among the serologically proven viral infections, adenovirus was the most frequent (53%), followed by parainfluenza (24%) and RSV (20%); 54% of the episodes lead to hospital admission. A significant change in microbial flora of respiratory secretions was seen in 88% of the episodes, mainly with P. aeruginosa, and 65% of cases with initial colonization with P. aeruginosa are associated with a viral respiratory tract infection. It is hypothesised that viral respiratory infections to a predamaged lung in CF predispose to colonization with P. aeruginosa. Many of the CF-patients show elevated serum IgG to C. albicans, and therefore, C. albicans should not be considered a harmless colonizing mold. The prevalence of A. fumigatus increases with age. Of the CF-patients with A. fumigatus, 73% showed elevated specific serum IgG to this fungus. No correlation was found between culture, specified IgG to A. fumigatus and either specific Aspergillus IgE or total serum IgE. Maintaining good pulmonary condition and reduction of exposure to A. fumigatus may prevent colonization and infection with this mold.


Cystic Fibrosis Respiratory Syncytial Virus Invasive Aspergillosis Microbial Flora Initial Colonization 
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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1996

Authors and Affiliations

  • Barbara Przyklenk
    • 1
  • Adolf Bauernfeind
    • 2
  1. 1.University Children’s HospitalLudwig-Maximilians-UniversitätMünchenGermany
  2. 2.Max von Pettenkofer-InstitutLudwig-Maximilians-UniversitätMunchenGermany

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