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Influence of Experimental Variables on DSC Curves

  • A. A. van Dooren

Abstract

Differential Scanning Calorimetry (DSC) is widely regarded as an important analytical tool in pharmaceutical research. It is well-known, however, that experimental factors can influence the results considerably. These factors relate to:
  1. 1.

    The adjustment of the apparatus, such as heating rate and calorimetric sensitivity.

     
  2. 2.

    The sample’s mass, packing and porosity, particle size (distributions), pretreatment and dilution.

     
  3. 3.

    The reference material’s mass, nature and pretreatment.

     
  4. 4.

    The atmosphere: thermal conductivity, oxidising or inert nature, static or flowing conditions.

     

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References

  1. 1.
    A. Gäumann, J. Oswald. Chimia21 (1967), 421–426Google Scholar
  2. 2.
    ICTA recommendations on nomenclature and reporting of thermal analysis data (1977)Google Scholar
  3. 3.
    H.E. Kissinger, Anal.Chem. 29 (1957), 1702 – 1706CrossRefGoogle Scholar
  4. 4.
    E.M. Barrall, L.B. Rogers, Anal.Chem. 34 (1962), 1101 – 1106CrossRefGoogle Scholar

Copyright information

© Springer Basel AG 1980

Authors and Affiliations

  • A. A. van Dooren
    • 1
  1. 1.Philips Duphar B.V.WeespThe Netherlands

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