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The Therapeutic Place and Value of Present and Future MAO-B Inhibitors — l-Deprenyl as the Gold Standard

  • P. Riederer
  • M. B. H. Youdim
Chapter
Part of the Milestones in Drug Therapy book series (MDT)

Abstract

The establishment of MAO inhibitors in the early 1960s failed, not because of the lack of intended efficacy but because of accompanying side-effects, e.g., hypotension and hypertension, psychic alteration, and hepatotoxicity. With Johnston’s discovery in 1968 of the multiple forms (MAO-A, MAO-B), selective MAO inhibitors could be developed for the first time that considered substrate specificity. Thus, there was hope to reduce the initially observed side-effects. l-Deprenyl (selegiline), synthesized by Ecsery and developed as an antidepressant drug by Knoll, was such a substance. As an antidepressant l-deprenyl did not succeed, but as an anti-Parkinson drug it did [1]. Meanwhile, l-deprenyl has become the “gold standard” of MAO inhibitors. The clinical and theoretical innovations of the last decade have been decisively marked by l-deprenyl since it unites many synergistic biochemical and pharmacological properties. Any new MAO-B inhibitor must have comparable properties since they determine the therapeutic value. Some of these new inhibitors will be reviewed here in comparison to l-deprenyl.

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© Springer Basel AG 1993

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  • P. Riederer
  • M. B. H. Youdim

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