Pharmacokinetic and Pharmacodynamical Models

  • João P. BelfoEmail author
  • João M. Lemos
Part of the SpringerBriefs in Electrical and Computer Engineering book series (BRIEFSELECTRIC)


This chapter presents the Pharmacokinetic (PK) and Pharmacodynamical (PD) models. Concerning PK models, empirical and mechanistic models are explained, including their advantages and disadvantages. Compartmental models are described, including a discussion on their properties: positivity, mass conservation and stability. For PD models, such as for the PK models, empirical models and mechanistic models are referred as well. The mechanistic model described by the Hill equation is studied for different drugs and configurations.


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© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

Authors and Affiliations

  1. 1.Control of Dynamical SystemsINESC-IDLisboaPortugal

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