45-Year-Old Man with Leg Pain and Numbness



Asymmetric and rapidly progressive painful sensorimotor disturbances raise concern for vasculitic neuropathy, the most common cause of which is non-systemic vasculitic neuropathy (NSVN). Nerve damage occurs by ischemic injury via mechanisms that differ between each process. The diagnosis is confirmed by history, examination, electrodiagnostic studies, laboratory findings, and likely nerve/muscle biopsy. Treatment is dependent on the underlying cause, and diagnosis is focused on evaluation for systemic vasculitides that can result in significant morbidity. In the case of NSVN, corticosteroids and consideration of other immunosuppressants are necessary to avoid further injury and disability.


Vasculitis Neuropathy Non-systemic vasculitic neuropathy Mononeuritis multiplex 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of Vermont Medical CenterBurlingtonUSA
  2. 2.Department of NeurosciencesUniversity of Vermont Medical CenterBurlingtonUSA

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