Hypothermic Machine Perfusion in Liver Transplantation Using Grafts From Donation After Circulatory Death Donors

  • Andrea Schlegel
  • Matteo Mueller
  • Philipp DutkowskiEmail author


Dynamic preservation strategies are a promising option to improve graft quality and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which is based on physiologic conditions, thereby aiming to simulate the human body, hypothermic oxygenated liver perfusion appears un-physiologic and induces a unique, mitochondrial response for its protective effect. Both ex vivo perfusion techniques can be used for viability assessment, which will open the door for an increased liver utilization in the future.


Oxidative injury Mitochondria Viability 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Andrea Schlegel
    • 1
  • Matteo Mueller
    • 2
  • Philipp Dutkowski
    • 2
    Email author
  1. 1.Liver UnitQueen Elizabeth Hospital BirminghamBirminghamUK
  2. 2.Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland

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