Biologics in Wound Management

  • Andrea De Pascalis
  • Valentina Dini


Biologics are a new class of drugs which mimic the action of human proteins and interact with circulating proteins or cellular/extracellular targets, blocking their activities. The main application of biologics in dermatology concerns psoriasis, atopic dermatitis, and recently hidradenitis suppurativa, with a growing interest in chronic wound management. Inflammatory wounds such as pyoderma gangrenosum and vasculitic ulcers are the main indications for biologics, according to the pathogenesis of them. Wondering the use of this drugs we have to consider the possible contraindications, side effects, and the remarkable costs. Checking the literature we can find just case reports or small case series about their use in chronic wound therapy.


Biologics Chronic wounds Skin ulcers Pyoderma gangrenosum Vasculitic ulcers 


Conflict of Interest

The authors declare no conflict of interest.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Andrea De Pascalis
    • 1
  • Valentina Dini
    • 1
  1. 1.Department of DermatologyUniversity of PisaPisaItaly

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