Extracellular Matrices

  • Andrea Ingegneri
  • Marco Romanelli


The skin is the largest organ in our body. The skin plays a barrier role, represents our first defense from toxic, infectious, or mechanical factors and regulates body temperature. It consists of different layers such as epidermis, dermis, and subcutaneous tissue. In the epidermal compartment, keratinocytes are arranged above the basal membrane, in a thin membranous layer composed of proteoglycans, glycoproteins, and collagen. In the dermis, there are two distinct extracellular matrix (ECM) and cell populations. Beneath the basal membrane there is the extracellular dermal matrix containing glycosaminoglycans (GAG), elastin, collagen, and cells like melanocytes, fibroblasts and endothelial cells. Skin wounds may represent a severe risk for patients, if the skin is not repaired and restored within an acceptable time.


Extracellular matrices Wound healing Tissue repair 


Conflict of Interest

The authors declare no conflict of interest for this chapter.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Andrea Ingegneri
    • 1
  • Marco Romanelli
    • 1
  1. 1.Department of DermatologyUniversity of PisaPisaItaly

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